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Sesquiterpenoids from Inula racemosa Hook. f. Inhibit Nitric Oxide Production
Zhang, SD; Qin, JJ; Jin, HZ; Yin, YH; Li, HL; Yang, XW; Li, X; Shan, L; Zhang, WD;;
Source PublicationPLANTA MEDICA
AbstractA novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC50 values of 7.39 +/- 0.36, 6.35 +/- 0.26, and 5.39 +/- 0.18 mu M, respectively.
Department[Yin, Yin-Hua; Li, Xia; Shan, Lei; Zhang, Wei-Dong] Mil Med Coll 2, Dept Nat Product Chem, Sch Pharm, Shanghai 200433, Peoples R China; [Zhang, Shou-De; Qin, Jiang-Jiang; Jin, Hui-Zi; Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China; [Li, Hong-Lin] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China
KeywordInula Racemosa Hook. F. Compositae Sesquiterpenes Density Functional Theory Nitric Oxide
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Funding ProjectLMB
Document Type期刊论文
Recommended Citation
GB/T 7714
Zhang, SD,Qin, JJ,Jin, HZ,et al. Sesquiterpenoids from Inula racemosa Hook. f. Inhibit Nitric Oxide Production[J]. PLANTA MEDICA,2012,78(2):166-171.
APA Zhang, SD.,Qin, JJ.,Jin, HZ.,Yin, YH.,Li, HL.,...& from Inula racemosa Hook. f. Inhibit Nitric Oxide Production.PLANTA MEDICA,78(2),166-171.
MLA Zhang, SD,et al."Sesquiterpenoids from Inula racemosa Hook. f. Inhibit Nitric Oxide Production".PLANTA MEDICA 78.2(2012):166-171.
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