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学科主题: Chemistry, Medicinal
题名: A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample
作者: Lin, XP ; Zhou, XF ; Wang, FZ ; Liu, KS ; Yang, B ; Yang, XW ; Peng, Y ; Liu, J ; Ren, Z ; Liu, YH
通讯作者: xiupinglin@hotmail.com ; xfzhou@scsio.ac.cn ; wangfazuo@scsio.ac.cn ; liukaisheng1987@163.com ; bingo525@163.com ; xwyang@scsio.ac.cn ; py00_2006@126.com ; ljuan2010@qq.com ; rz62@163.com ; yonghongliu@scsio.ac.cn
关键词: Penicillium sp F00120 ; sesquiterpene quinone ; cytotoxic ; deep sea sediment ; penicilliumin A
刊名: MARINE DRUGS
发表日期: 2012
卷: 10, 期:1, 页:106-115
部门归属: [Lin, Xiuping; Zhou, Xuefeng; Wang, Fazuo; Yang, Bin; Yang, Xianwen; Peng, Yan; Liu, Juan; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Kaisheng; Ren, Zhe] Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
项目归属: LMB
摘要: A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.
语种: 英语
WOS记录号: WOS:000299541800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10022
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Lin, XP; Zhou, XF; Wang, FZ; Liu, KS; Yang, B; Yang, XW; Peng, Y; Liu, J; Ren, Z; Liu, YH.A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample,MARINE DRUGS,2012,10(1):106-115
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