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学科主题: Chemistry
题名: New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141
作者: Zhou, X ; Huang, HB ; Li, J ; Song, YX ; Jiang, RW ; Liu, J ; Zhang, S ; Hua, Y ; Ju, JH
通讯作者: huayan@mail.kib.ac.cn ; jju@scsio.ac.cn
关键词: Cycloheptapeptide ; Streptomyces drozdowiczii ; Anti-infective ; Marine-derived actinomycete ; Marformycins A-F
刊名: TETRAHEDRON
发表日期: 2014
卷: 70, 期:42, 页:7795-7801
收录类别: sci
部门归属: [Zhou, Xiao ; Huang, Hongbo ; Li, Jie ; Song, Yongxiang ; Liu, Jing ; Zhang, Si ; Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Hua, Yan] Southwest Forestry Univ, Bailongsi, Kunming, Peoples R China ; [Jiang, Renwang] Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
项目归属: LMB
资助者: National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]
摘要: Six cycloheptadepsipeptides, marformycins A-F (1-6), featuring a unique N-terminally formylated side chain and five non-proteinogenic amino acid residues, were isolated from the deep Sea-derived Streptomyces drozdowiczii SCSIO 10141. The previously unsolved absolute stereochemistry of 3 and 4 was determined and the structures of other four new congeners were elucidated by extensive spectroscopic, chiral-phase HPLC, and single-crystal X-ray diffraction analyses. Compounds 1-5 bear no cytotoxicity against a number of human tumor cell lines but show selective anti-infective activity against Micrococcus luteus. (C) 2014 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000342711300029
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10370
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Zhou, X; Huang, HB; Li, J; Song, YX; Jiang, RW; Liu, J; Zhang, S; Hua, Y; Ju, JH.New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141,TETRAHEDRON,2014,70(42):7795-7801
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