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New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141
Zhou, X; Huang, HB; Li, J; Song, YX; Jiang, RW; Liu, J; Zhang, S; Hua, Y; Ju, JH; huayan@mail.kib.ac.cn; jju@scsio.ac.cn
2014
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume70Issue:42Pages:7795-7801
AbstractSix cycloheptadepsipeptides, marformycins A-F (1-6), featuring a unique N-terminally formylated side chain and five non-proteinogenic amino acid residues, were isolated from the deep Sea-derived Streptomyces drozdowiczii SCSIO 10141. The previously unsolved absolute stereochemistry of 3 and 4 was determined and the structures of other four new congeners were elucidated by extensive spectroscopic, chiral-phase HPLC, and single-crystal X-ray diffraction analyses. Compounds 1-5 bear no cytotoxicity against a number of human tumor cell lines but show selective anti-infective activity against Micrococcus luteus. (C) 2014 Elsevier Ltd. All rights reserved.
Department[Zhou, Xiao ; Huang, Hongbo ; Li, Jie ; Song, Yongxiang ; Liu, Jing ; Zhang, Si ; Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Hua, Yan] Southwest Forestry Univ, Bailongsi, Kunming, Peoples R China ; [Jiang, Renwang] Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
KeywordCycloheptapeptide Streptomyces Drozdowiczii Anti-infective Marine-derived Actinomycete Marformycins A-f
Subject AreaChemistry
Funding OrganizationNational Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12] ; National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12] ; National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12] ; National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]
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Indexed Bysci
Funding ProjectLMB
Funding OrganizationNational Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12] ; National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12] ; National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12] ; National Natural Science Foundation of China [41106138, 41206135]; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]
WOS IDWOS:000342711300029
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10370
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorhuayan@mail.kib.ac.cn; jju@scsio.ac.cn
Recommended Citation
GB/T 7714
Zhou, X,Huang, HB,Li, J,et al. New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141[J]. TETRAHEDRON,2014,70(42):7795-7801.
APA Zhou, X.,Huang, HB.,Li, J.,Song, YX.,Jiang, RW.,...&jju@scsio.ac.cn.(2014).New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141.TETRAHEDRON,70(42),7795-7801.
MLA Zhou, X,et al."New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141".TETRAHEDRON 70.42(2014):7795-7801.
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