中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Pharmacology & Pharmacy ; Chemistry
题名: Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans
作者: Wang, JF ; Deng, YH ; Yang, SH ; Liu, YQ ; Wang, YH ; Pan, WW ; Zhou, XJ
通讯作者: gale9888@163.com
关键词: Zanthoxylum simulans ; Dimeric lignans ; Synovial cells ; Splenocytes
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2014
卷: 24, 期:19, 页:4667-4671
收录类别: sci
部门归属: [Deng, Yi-Hui ; Yang, Sheng-Hui ; Liu, Yan-Qun ; Pan, Wei-Wei ; Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China ; [Wang, Jun-Feng] Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guand, Guangzhou 510301, Guangdong, Peoples R China ; [Deng, Yi-Hui] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China ; [Wang, Yue-Hu] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
项目归属: LMB
资助者: National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085]
摘要: Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000342574600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10378
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Wang-2014-Characterization and.pdf(1369KB)----开放获取View 联系获取全文

Recommended Citation:
Wang, JF; Deng, YH; Yang, SH; Liu, YQ; Wang, YH; Pan, WW; Zhou, XJ.Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, JF]'s Articles
[Deng, YH]'s Articles
[Yang, SH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, JF]‘s Articles
[Deng, YH]‘s Articles
[Yang, SH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Wang-2014-Characterization and.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace