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Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans
Wang, JF; Deng, YH; Yang, SH; Liu, YQ; Wang, YH; Pan, WW; Zhou, XJ; gale9888@163.com
2014
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume24Issue:19Pages:4667-4671
AbstractInvestigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual alpha,beta-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 mu M, and 13.8 to 74.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
Department[Deng, Yi-Hui ; Yang, Sheng-Hui ; Liu, Yan-Qun ; Pan, Wei-Wei ; Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China ; [Wang, Jun-Feng] Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol,Guand, Guangzhou 510301, Guangdong, Peoples R China ; [Deng, Yi-Hui] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China ; [Wang, Yue-Hu] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
KeywordZanthoxylum Simulans Dimeric Lignans Synovial Cells Splenocytes
Subject AreaPharmacology & Pharmacy ; Chemistry
Funding OrganizationNational Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085] ; National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085] ; National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085] ; National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085]
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Indexed Bysci
Funding ProjectLMB
Funding OrganizationNational Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085] ; National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085] ; National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085] ; National Natural Science Foundation of China [31170336]; Hunan Provincial Natural Science Foundation, China [14JJ2108]; Hunan Province University Innovation Platform Open Foundation, China [12K085]
WOS IDWOS:000342574600011
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Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10378
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorgale9888@163.com
Recommended Citation
GB/T 7714
Wang, JF,Deng, YH,Yang, SH,et al. Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(19):4667-4671.
APA Wang, JF.,Deng, YH.,Yang, SH.,Liu, YQ.,Wang, YH.,...&gale9888@163.com.(2014).Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(19),4667-4671.
MLA Wang, JF,et al."Characterization and biological evaluation of six new dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum simulans".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.19(2014):4667-4671.
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