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学科主题: Biotechnology & Applied Microbiology
题名: Antifungal effect and mechanism of garlic oil on Penicillium funiculosum
作者: Li, WR ; Shi, QS ; Liang, Q ; Huang, XM ; Chen, YB
通讯作者: jigan@gdim.cn
关键词: Garlic oil ; Antifungal effects ; Antifungal mechanism ; Penicillium funiculosum
刊名: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
发表日期: 2014
卷: 98, 期:19, 页:8337-8346
收录类别: sci
部门归属: [Li, Wen-Ru ; Shi, Qing-Shan ; Liang, Qing ; Huang, Xiao-Mo ; Chen, Yi-Ben] Guangdong Inst Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, State Key Lab Appl Microbiol Southern China, Guangzhou 510070, Guangdong, Peoples R China ; [Liang, Qing] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
资助者: Guangdong Provincial Science and Technology Project [2009B011000011, 2011B010400039]; Foshan City; Chinese Academy of Sciences [2012HY100115]
摘要: Garlic oil is a kind of fungicide, but little is known about its antifungal effects and mechanism. In this study, the chemical constituents, antifungal activity, and effects of garlic oil were studied with Penicillium funiculosum as a model strain. Results showed that the minimum fungicidal concentrations (MFCs, v/v) were 0.125 and 0.0313 % in agar medium and broth medium, respectively, suggesting that the garlic oil had a strong antifungal activity. The main ingredients of garlic oil were identified as sulfides, mainly including disulfides (36 %), trisulfides (32 %) and monosulfides (29 %) by gas chromatograph-mass spectrometer (GC/MS), which were estimated as the dominant antifungal factors. The observation results by transmission electron microscope (TEM) and scanning electron microscope (SEM) indicated that garlic oil could firstly penetrate into hyphae cells and even their organelles, and then destroy the cellular structure, finally leading to the leakage of both cytoplasm and macromolecules. Further proteomic analysis displayed garlic oil was able to induce a stimulated or weakened expression of some key proteins for physiological metabolism. Therefore, our study proved that garlic oil can work multiple sites of the hyphae of P. funiculosum to cause their death. The high antifungal effects of garlic oil makes it a broad application prospect in antifungal industries.
原文出处: 查看原文
WOS记录号: WOS:000342072500024
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10383
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Li, WR; Shi, QS; Liang, Q; Huang, XM; Chen, YB.Antifungal effect and mechanism of garlic oil on Penicillium funiculosum,APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2014,98(19):8337-8346
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