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学科主题: Chemistry
题名: Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors
作者: Ai, W ; Wei, XY ; Lin, XP ; Sheng, L ; Wang, Z ; Tu, ZC ; Yang, XW ; Zhou, XF ; Li, J ; Liu, YH
通讯作者: jli@mail.shcnc.ac.cn ; yonghongliu@scsio.ac.cn
关键词: Spirodioxynaphthalene ; Kandelia candel ; Mangrove plant ; Endophytic fungus ; Guignardia sp.
刊名: TETRAHEDRON
发表日期: 2014
卷: 70, 期:35, 页:5806-5814
收录类别: sci
部门归属: [Ai, Wen ; Lin, Xiuping ; Yang, Xianwen ; Zhou, Xuefeng ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Ai, Wen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Wei, Xiaoyi] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China ; [Sheng, Li ; Li, Jia] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China ; [Wang, Zhen ; Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
项目归属: LMB
资助者: National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2013AA092901, 2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
摘要: Six new guignardins A-F (1-6) were isolated from the cultures of endophytic fungus Guignardia sp. KcF8 derived of a mangrove plant Kandelia candel, along with three known analogues, palmarumycins C-1 (7), BG1 (8), and JC1 (9). Compounds 2, 3, 7, and 8 showed antimicrobial activities. Compounds 5-7 exhibited significant cytotoxicities against 10 human tumor cell lines. Compound 3 also displayed significant inhibitory activity against human protein tyrosine phosphatase 1B and histone deacetylase silent information regulator T-1 enzymes, two key targets for the treatment of diabetes. This is the first report on the anti-PTP1B and anti-SIRT1 activities of spirodioxynaphthalenes. (C) 2014 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000340336000055
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10385
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Ai, W; Wei, XY; Lin, XP; Sheng, L; Wang, Z; Tu, ZC; Yang, XW; Zhou, XF; Li, J; Liu, YH.Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors,TETRAHEDRON,2014,70(35):5806-5814
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