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学科主题: Biochemistry & Molecular Biology ; Plant Sciences
题名: Chemical constituents of Abies delavayi
作者: Yang, XW ; Li, SM ; Li, YL ; Feng, L ; Shen, YH ; Lin, S ; Tian, JM ; Zeng, HW ; Wang, N ; Steinmetz, A ; Liu, YH ; Zhang, WD
通讯作者: wdzhangy@hotmail.com
关键词: Abies delavayi ; Pinaceae ; Sesquiterpenes ; Monoterpenes ; Triterpenoids ; Phenols ; Cytotoxicity ; Nitric oxide (NO)
刊名: PHYTOCHEMISTRY
发表日期: 2014
卷: 105, 页:164-170
收录类别: sci
部门归属: [Yang, Xian-Wen ; Li, Yong-Li ; Feng, Lin ; Shen, Yun-Heng ; Lin, Shen ; Tian, Jun-Mian ; Zeng, Hua-Wu ; Zhang, Wei-Dong] Second Mil Med Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai, Peoples R China ; [Yang, Xian-Wen ; Li, Su-Mei ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, Beijing 100864, Peoples R China ; [Yang, Xian-Wen ; Wang, Ning ; Steinmetz, Andre] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg
项目归属: LMB
资助者: NCET Foundation; NSFC [81230090, 41176148, 21372233]; Global Research Network for Medicinal Plants (GRNMP); King Saud University; FP7-PEO-PLE-IRSES (TCMCANCER Project) [230232]; Key laboratory of drug research for special environments; PLA; Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]; Scientific Foundation of Shanghai China [09DZ1975700, 09DZ1971500, 10DZ197 1700]; National Major Project of China [2011ZX09307-002-03]; National Key Technology R&D Program of China [2012BAI 29B06]; Shanghai Leading Academic Discipline Project [B906]
摘要: Systematic phytochemical investigations on Abies delavayi afforded 110 compounds, including 49 terpenoids, 13 lignans, 20 flavonoids, three coumarins, and 25 other chemical constituents. By detailed analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data, 10 previously unreported compounds were identified: they comprised three sesquiterpenoids, two diterpenoids, one triterpenoid, one monoterpenoid, one flavonoid, and two phenols. These 10 compounds and some previously known ones were subjected to two cytotoxic bioassays against three human tumor cell lines and NO production inhibition on RAW264.7 macrophages, respectively. (25R)-24,25-Dihydroabieslactone had the strongest cytotoxic activity against Colo-205 cells with an IC50 value of 19.0 +/- 3.7 mu g/mL. (+)-T-cadinol, 8,11,13-abietatrien-15-ol-18-yl acetate, 18-acetoxy-13-epi-manool, imperatorin, bergapten, and 5,7-O-dimethyl poriol exhibited weak inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values of approximately 50 mu g/mL. (C) 2014 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000340986900021
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10391
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Yang, XW; Li, SM; Li, YL; Feng, L; Shen, YH; Lin, S; Tian, JM; Zeng, HW; Wang, N; Steinmetz, A; Liu, YH; Zhang, WD.Chemical constituents of Abies delavayi,PHYTOCHEMISTRY,2014,105():164-170
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