Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase
Ji, CT; Chen, Q; Li, QL; Huang, HB; Song, YX; Ma, JY; Ju, JH; jju@scsio.ac.cn
2014
发表期刊TETRAHEDRON LETTERS
ISSN0040-4039
卷号55期号:35页码:4901-4904
摘要McbA was characterized in vitro as a novel amide synthetase in the marinacarbolines A-D biosynthetic pathway, catalyzing amide bond formation between 1-acetyl-3-carboxy-beta-carboline (la) and substituted-beta-phenethylamines (1b, 213, 3b) and tryptamine (4b) in an ATP-dependent manner. Enzyme kinetic analyses highlight beta-phenethylamine as the most suitable amine donor. McbA showed broad substrate compatibility with substituted amines; 10 new beta-carboline analogues were chemoenzymatically generated. (C) 2014 Elsevier Ltd. All rights reserved.
部门归属[Ji, Changtao ; Chen, Qi ; Li, Qinglian ; Huang, Hongbo ; Song, Yongxiang ; Ma, Junying ; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China ; [Ji, Changtao ; Chen, Qi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
关键词Amide Synthetase Beta-carboline Mcba Chemoenzymatic Synthesis
学科领域Chemistry
资助者MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606]
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收录类别sci
资助项目LMB
资助者MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606]
WOS记录号WOS:000340985800013
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10396
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn
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GB/T 7714
Ji, CT,Chen, Q,Li, QL,et al. Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase[J]. TETRAHEDRON LETTERS,2014,55(35):4901-4904.
APA Ji, CT.,Chen, Q.,Li, QL.,Huang, HB.,Song, YX.,...&jju@scsio.ac.cn.(2014).Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase.TETRAHEDRON LETTERS,55(35),4901-4904.
MLA Ji, CT,et al."Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase".TETRAHEDRON LETTERS 55.35(2014):4901-4904.
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