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学科主题: Chemistry
题名: Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation
作者: Fu, P ; Zhu, YG ; Mei, XG ; Wang, Y ; Jia, HJ ; Zhang, CS ; Zhu, WM
通讯作者: czhang2006@gmail.com ; weimingzhu@ouc.edu.cn
刊名: ORGANIC LETTERS
发表日期: 2014
卷: 16, 期:16, 页:4264-4267
收录类别: sci
部门归属: [Fu, Peng ; Mei, Xiangui ; Wang, Yi ; Jia, Haijian ; Zhu, Weiming] Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China ; [Zhu, Yiguang ; Zhang, Changsheng] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
资助者: NSFC [21172204, 41376148, 81373298, 31070045, 31125001]; 973 Program of China [2010CB833800]; Public Science and Technology Research Funds Projects of Ocean [201405038]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-002]
摘要: Inactivation of the O-methyltransferase gene crmM of Actinoalloteichus cyanogriseus WH1-2216-6 led to a mutant that produced three new acyclic bipyridine glycosides, cyanogrisides E-G (1-3). Further chemical analysis of the wild strain yielded 1 and another new analogue, cyanogriside H (4). Compounds 1-4 possess a skeleton consisting of a 2,2'-bipyridine and a D-quinovose or L-rhamnose sugar moiety. Cyanogriside G (3) was considered to be a key biosynthetic intermediate of the cyclic bipyridine glycosides cyanogrisides A-D. Compounds 2 and 3 showed cytotoxicities against HCTI16 and HL-60 cells, and compounds 1 and 4 were cytotoxic on K562 cells.
原文出处: 查看原文
WOS记录号: WOS:000340517200053
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10402
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Fu, P; Zhu, YG; Mei, XG; Wang, Y; Jia, HJ; Zhang, CS; Zhu, WM.Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation,ORGANIC LETTERS,2014,16(16):4264-4267
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