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学科主题: Plant Sciences ; Pharmacology & Pharmacy
题名: Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
作者: Song, YX ; Li, QL ; Liu, X ; Chen, YC ; Zhang, Y ; Sun, AJ ; Zhang, WM ; Zhang, JR ; Ju, JH
通讯作者: jju@scsio.ac.cn
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2014
卷: 77, 期:8, 页:1937-1941
收录类别: sci
部门归属: [Song, Yongxiang ; Li, Qinglian ; Zhang, Yun ; Sun, Aijun ; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China ; [Liu, Xue ; Zhang, Jingren] Tsinghua Univ, Sch Med, Ctr Infect Dis Res, Beijing 100084, Peoples R China ; [Chen, Yuchan ; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
项目归属: LMB
资助者: National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001]
摘要: Three new cyclohexapeptides, desotamides B-D (2-4), and the known desotamide (1) were isolated from marine microbe Streptomyces scopuliridis SCSIO ZJ46. The sequences and absolute configurations of 2-4 were elucidated on the basis of high-resolution spectroscopic data, Marfey's method, and chiral-phase HPLC data. Desotamide C (3) contains a unique N-formyl-kynurenine residue, whereas 4 lacks formylation at the same site. Compounds 1 and 2 displayed notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE), and structure activity relationship studies revealed the indispensability of the Tip component for antibacterial activity within this new scaffold.
原文出处: 查看原文
WOS记录号: WOS:000340861800023
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10412
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Song, YX; Li, QL; Liu, X; Chen, YC; Zhang, Y; Sun, AJ; Zhang, WM; Zhang, JR; Ju, JH.Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria,JOURNAL OF NATURAL PRODUCTS,2014,77(8):1937-1941
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