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Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
Song, YX; Li, QL; Liu, X; Chen, YC; Zhang, Y; Sun, AJ; Zhang, WM; Zhang, JR; Ju, JH; jju@scsio.ac.cn
2014
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume77Issue:8Pages:1937-1941
AbstractThree new cyclohexapeptides, desotamides B-D (2-4), and the known desotamide (1) were isolated from marine microbe Streptomyces scopuliridis SCSIO ZJ46. The sequences and absolute configurations of 2-4 were elucidated on the basis of high-resolution spectroscopic data, Marfey's method, and chiral-phase HPLC data. Desotamide C (3) contains a unique N-formyl-kynurenine residue, whereas 4 lacks formylation at the same site. Compounds 1 and 2 displayed notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE), and structure activity relationship studies revealed the indispensability of the Tip component for antibacterial activity within this new scaffold.
Department[Song, Yongxiang ; Li, Qinglian ; Zhang, Yun ; Sun, Aijun ; Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China ; [Liu, Xue ; Zhang, Jingren] Tsinghua Univ, Sch Med, Ctr Infect Dis Res, Beijing 100084, Peoples R China ; [Chen, Yuchan ; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] ; National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] ; National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] ; National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001]
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Indexed Bysci
Funding ProjectLMB
Funding OrganizationNational Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] ; National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] ; National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] ; National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001]
WOS IDWOS:000340861800023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10412
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorjju@scsio.ac.cn
Recommended Citation
GB/T 7714
Song, YX,Li, QL,Liu, X,et al. Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1937-1941.
APA Song, YX.,Li, QL.,Liu, X.,Chen, YC.,Zhang, Y.,...&jju@scsio.ac.cn.(2014).Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria.JOURNAL OF NATURAL PRODUCTS,77(8),1937-1941.
MLA Song, YX,et al."Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1937-1941.
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