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学科主题: Pharmacology & Pharmacy
题名: New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius
作者: Bai, ZQ ; Lin, XP ; Wang, YZ ; Wang, JF ; Zhou, XF ; Yang, B ; Liu, J ; Yang, XW ; Wang, Y ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
关键词: Butyrolactones ; Endophytic fungus ; Aspergillus flavipes ; Mangrove plant ; Acanthus ilicifolius
刊名: FITOTERAPIA
发表日期: 2014
卷: 95, 页:194-202
收录类别: sci
部门归属: [Bai, Zhi-Qiang ; Lin, Xiuping ; Wang, Junfeng ; Zhou, Xuefeng ; Yang, Bin ; Liu, Juan ; Yang, Xianwen ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol Guang, Guangzhou 510301, Guangdong, Peoples R China ; [Bai, Zhi-Qiang ; Lin, Xiuping ; Wang, Junfeng ; Zhou, Xuefeng ; Yang, Bin ; Liu, Juan ; Yang, Xianwen ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China ; [Bai, Zhi-Qiang] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China ; [Wang, Yizhu ; Wang, Yi] China Acad Chinese Med Sci, Expt Res Ctr, Beijing 100700, Peoples R China ; [Wang, Yizhu] Jilin Univ, Sch Basic Med Sci, Dept Genet, Changchun 130021, Peoples R China
项目归属: LMB
资助者: National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 30973679, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
摘要: Two new aromatic butyrolactones, flavipesins A (1) and B (2), two new natural products (3 and 4), and a known phenyl dioxolanone (5) were isolated from marine-derived endophytic fungus Aspergillus flavipes. The structures of compounds 1-5 were elucidated by 1D- and 2D-NMR and MS analysis, the absolute configurations were assigned by optical rotation and CD data, and the stereochemistry of 1 was determined by X-ray crystallography analysis. I demonstrated lower MIC values against Staphylococcus aureus (8.0 mu g/mL) and Bacillus subtillis (0.25 mu g/mL). I also showed the unique antibiofilm activity of penetration through the biofilm matrix and kills live bacteria inside mature S. aureus biofilm. (C) 2014 Elsevier B.V. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000336819400027
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10434
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Bai, ZQ; Lin, XP; Wang, YZ; Wang, JF; Zhou, XF; Yang, B; Liu, J; Yang, XW; Wang, Y; Liu, YH.New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius,FITOTERAPIA,2014,95():194-202
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