Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship
Bao, J; Luo, JF; Qin, XC; Xu, XY; Zhang, XY; Tu, ZC; Qi, SH; tu_zhengchao@gibh.ac.cn; shuhuaqi@scsio.ac.cn
2014
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号24期号:11页码:2433-2436
摘要Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D-E (1-2) and known oxalicumones A-B (3-4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1-2 were elucidated by spectroscopic analysis. Eleven derivatives 3a-3i and 4a-4b were obtained from the acylation of 3 and 4, respectively. Compounds 1-4, 3a-3e, 3g-3h, and 4b showed significant cytotoxicity against several carcinoma cell lines with IC50 <= 10 mu M. And their structure-bioactivity relationship was discussed. (C) 2014 Elsevier Ltd. All rights reserved.
部门归属[Bao, Jie ; Xu, Xin-Ya ; Zhang, Xiao-Yong ; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Bao, Jie] Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Luo, Jin-Feng ; Qin, Xiao-Chu ; Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
关键词Penicillium Oxalicum Dihydrothiophene-condensed Chromones Cytotoxicity Structure-bioactivity Relationship
学科领域Pharmacology & Pharmacy ; Chemistry
资助者National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] ; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] ; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] ; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104]
URL查看原文
收录类别sci
资助项目LMB
资助者National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] ; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] ; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] ; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104]
WOS记录号WOS:000335518300008
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10435
专题中科院海洋生物资源可持续利用重点实验室
通讯作者tu_zhengchao@gibh.ac.cn; shuhuaqi@scsio.ac.cn
推荐引用方式
GB/T 7714
Bao, J,Luo, JF,Qin, XC,et al. Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(11):2433-2436.
APA Bao, J.,Luo, JF.,Qin, XC.,Xu, XY.,Zhang, XY.,...&shuhuaqi@scsio.ac.cn.(2014).Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(11),2433-2436.
MLA Bao, J,et al."Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.11(2014):2433-2436.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S0960894X1400(484KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。