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学科主题: Pharmacology & Pharmacy ; Chemistry
题名: Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship
作者: Bao, J ; Luo, JF ; Qin, XC ; Xu, XY ; Zhang, XY ; Tu, ZC ; Qi, SH
通讯作者: tu_zhengchao@gibh.ac.cn ; shuhuaqi@scsio.ac.cn
关键词: Penicillium oxalicum ; Dihydrothiophene-condensed chromones ; Cytotoxicity ; Structure-bioactivity relationship
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2014
卷: 24, 期:11, 页:2433-2436
收录类别: sci
部门归属: [Bao, Jie ; Xu, Xin-Ya ; Zhang, Xiao-Yong ; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Bao, Jie] Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Luo, Jin-Feng ; Qin, Xiao-Chu ; Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China
项目归属: LMB
资助者: National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104]
摘要: Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D-E (1-2) and known oxalicumones A-B (3-4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1-2 were elucidated by spectroscopic analysis. Eleven derivatives 3a-3i and 4a-4b were obtained from the acylation of 3 and 4, respectively. Compounds 1-4, 3a-3e, 3g-3h, and 4b showed significant cytotoxicity against several carcinoma cell lines with IC50 <= 10 mu M. And their structure-bioactivity relationship was discussed. (C) 2014 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000335518300008
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10435
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Bao, J; Luo, JF; Qin, XC; Xu, XY; Zhang, XY; Tu, ZC; Qi, SH.Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(11):2433-2436
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