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学科主题: Chemistry
题名: Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis
作者: Zhang, GT ; Zhang, WJ ; Zhang, QB ; Shi, T ; Ma, L ; Zhu, YG ; Li, SM ; Zhang, HB ; Zhao, YL ; Shi, R ; Zhang, CS
通讯作者: czhang2006@gmail.com
关键词: biosynthesis ; heterologous expression ; ikarugamycin ; polycyclic tetramate macrolactams ; reductive cyclization
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
发表日期: 2014
卷: 53, 期:19, 页:4840-4844
收录类别: sci
部门归属: [Zhang, Guangtao ; Zhang, Wenjun ; Zhang, Qingbo ; Ma, Liang ; Zhu, Yiguang ; Li, Sumei ; Zhang, Haibo ; Zhang, Changsheng] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Shi, Ting ; Zhao, Yi-Lei] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China ; [Shi, Ting ; Zhao, Yi-Lei] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China ; [Shi, Rong] Univ Laval, PROTEO, Dept Biochim Microbiol & Bioinformat, Quebec City, PQ G1V 0A6, Canada ; [Shi, Rong] Univ Laval, IBIS, Quebec City, PQ G1V 0A6, Canada
项目归属: LMB
资助者: National Natural Science Foundation of China [31125001, 21377085]; Ministry of Science and Technology of China [2010CB833805, 2012AA092104]; Chinese Academy of Sciences [XDA11030403]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
摘要: Ikarugamycin is a member of the polycyclic tetramate macrolactams (PTMs) family of natural products with diverse biological activities. The biochemical mechanisms for the formation of polycyclic ring systems in PTMs remain elusive. The enzymatic mechanism of constructing an inner five-membered ring in ikarugamycin is reported. A three-gene-cassette ikaABC from the marine-derived Streptomyces sp. ZJ306 is sufficient for conferring ikarugamycin production in a heterologous host. IkaC catalyzes a reductive cyclization reaction to form the inner five-membered ring by a Michael addition-like reaction. This study provides the first biochemical evidence for polycycle formation in PTMs and suggests a reductive cyclization strategy which may be potentially applicable in general to the corresponding ring formation in other PTMs.
原文出处: 查看原文
WOS记录号: WOS:000335202700013
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10440
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Zhang, GT; Zhang, WJ; Zhang, QB; Shi, T; Ma, L; Zhu, YG; Li, SM; Zhang, HB; Zhao, YL; Shi, R; Zhang, CS.Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis,ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(19):4840-4844
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