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学科主题: Pharmacology & Pharmacy
题名: Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro
作者: Liu, JX ; Luo, MQ ; Xia, M ; Wu, Q ; Long, SM ; Hu, YH ; Gao, GC ; Yao, XL ; He, MA ; Su, HX ; Luo, XM ; Yao, SZ
通讯作者: liujxiu@mail.sysu.edu.cn ; zhanglmq@sina.com ; xiameng25@163.com ; wuqi@medmail.com.cn ; ivylsm@163.com ; yaohuahu225@aliyun.com ; gaogcjx@163.com ; liliyao71@163.com ; gz87335487@163.net ; Huanxingsu@umac.mo ; xiongmingluo@scsio.ac.cn ; yaoshuzh@mail.sysu.edu.cn
关键词: anti-angiogenesis ; catunaregin ; VEGF ; zebrafish ; HUVECs
刊名: MARINE DRUGS
发表日期: 2014
卷: 12, 期:5, 页:2790-2801
收录类别: sci
部门归属: [Liu, Jun-Xiu ; Xia, Meng ; He, Mian ; Yao, Shu-Zhong] Sun Yat Sen Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China ; [Luo, Min-Qi] Sun Yat Sen Univ, Dept Clin Lab, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China ; [Wu, Qi ; Long, Si-Mei ; Yao, Xiao-Li] Sun Yat Sen Univ, Guangdong Key Lab Diag & Treatment Major Neurol D, Dept Neurol, Natl Key Clin Dept,Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China ; [Wu, Qi ; Long, Si-Mei ; Yao, Xiao-Li] Sun Yat Sen Univ, Key Discipline Neurol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China ; [Hu, Yaohua ; Su, Huanxing] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macao 999078, Peoples R China ; [Gao, Guang-Chun] Jiaxing Univ, Coll Med, Jiaxing 314001, Peoples R China ; [Luo, Xiong-Ming] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
资助者: National Key Clinical Department; National Key Discipline; Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases; National Natural Science Foundation of China [81371255, 81100936]; Doctoral Program of Higher Education of China [20110171110058]; Young Scientists Fund of the National Natural Science Foundation of China [41006091]; Guangdong Technological grant [2010B050700024, 2011B050400031, 2012B031800107]; Natural Science Foundation of Guangdong Province [S2011010004860]; Sun Yat-sen University [2007010]; university of Macau [MYRG122 (Y1-L3)-ICMS12-SHX]
摘要: Angiogenesis is the formation of blood vessels from pre-existing vasculature. Excessive or uncontrolled angiogenesis is a major contributor to many pathological conditions whereas inhibition of aberrant angiogenesis is beneficial to patients with pathological angiogenesis. Catunaregin is a core of novel marine compound isolated from mangrove associate. The potential anti-angiogenesis of catunaregin was investigated in human umbilical vein endothelial cells (HUVECs) and zebrafish. HUVECs were treated with different concentrations of catunaregin in the presence or absence of VEGF. The angiogenic phenotypes including cell invasion cell migration and tube formation were evaluated following catunaregin treatment in HUVECs. The possible involvement of AKT, eNOS and ERK1/2 in catunaregin-induced anti-angiogenesis was explored using Western blotting. The anti-angiogenesis of catunaregin was further tested in the zebrafish embryo neovascularization and caudal fin regeneration assays. We found that catunaregin dose-dependently inhibited angiogenesis in both HUVECs and zebrafish embryo neovascularization and zebrafish caudal fin regeneration assays. In addition, catunaregin significantly decreased the phosphorylation of Akt and eNOS, but not the phosphorylation of ERK1/2. The present work demonstrates that catunaregin exerts the anti-angiogenic activity at least in part through the regulation of the Akt and eNOS signaling pathways.
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WOS记录号: WOS:000337160500024
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10442
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Liu, JX; Luo, MQ; Xia, M; Wu, Q; Long, SM; Hu, YH; Gao, GC; Yao, XL; He, MA; Su, HX; Luo, XM; Yao, SZ.Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro,MARINE DRUGS,2014,12(5):2790-2801
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