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学科主题: Marine & Freshwater Biology ; Toxicology
题名: The synthetic progestin megestrol acetate adversely affects zebrafish reproduction
作者: Han, J ; Wang, QW ; Wang, XF ; Li, YG ; Wen, S ; Liu, S ; Ying, GG ; Guo, YY ; Zhou, BS
通讯作者: bszhou@ihb.ac.cn
关键词: Progestin ; Endocrine disruption ; Reproduction ; Hypothalamic-pituitary-gonadal axis
刊名: AQUATIC TOXICOLOGY
发表日期: 2014
卷: 150, 页:66-72
收录类别: sci
部门归属: [Han, Jian ; Wang, Qiangwei ; Wang, Xianfeng ; Guo, Yongyong ; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; [Han, Jian ; Wang, Qiangwei ; Wang, Xianfeng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Li, Yonggang ; Wen, Sheng] Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Peoples R China ; [Liu, Shan] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China ; [Ying, Guangguo] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China
项目归属: LMB
资助者: National Natural Science Foundation of China [21277170]; State Key Laboratory of Freshwater Ecology and Biotechnology [2011FBZ13]
摘要: Synthetic progestins contaminate the aquatic ecosystem, and may cause adverse health effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment, but its possible effects on fish reproduction are unknown. In the present study, we investigated the endocrine disruption and impact of MTA on fish reproduction. After a pre-exposure period of 14 days, reproductively mature zebrafish (Danio rerio) (F0) were exposed to MTA at environmental concentrations (33, 100, 333, and 666 ng/L) for 21 days. Egg production was decreased in F0 fish exposed to MTA, with a significant decrease at 666 ng/L. The exposure significantly decreased the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-keto testosterone (11-KT) in male fish. MTA exposure significantly downregulated the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. MTA did not affect early embryonic development or hatching success in the F1 generation. The present study showed that MTA is a potent endocrine disruptor in fish, and short-term exposure to MTA could significantly affect reproduction in fish and negatively impact the fish population. (C) 2014 Elsevier B.V. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000336187900008
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10443
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Han, J; Wang, QW; Wang, XF; Li, YG; Wen, S; Liu, S; Ying, GG; Guo, YY; Zhou, BS.The synthetic progestin megestrol acetate adversely affects zebrafish reproduction,AQUATIC TOXICOLOGY,2014,150():66-72
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