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学科主题: Chemistry ; Pharmacology & Pharmacy
题名: Three new polyketides from marine-derived fungus Penicillium citrinum SCSGAF 0167
作者: Sun, YL ; Zhang, XY ; Zheng, ZH ; Xu, XY ; Qi, SH
通讯作者: shuhuaqi@scsio.ac.cn
关键词: Penicillium citrinum ; polyketide ; cathepsin B inhibitor
刊名: NATURAL PRODUCT RESEARCH
发表日期: 2014
卷: 28, 期:4, 页:239-244
收录类别: sci
部门归属: [Sun, Yu-Lin ; Zhang, Xiao-Yong ; Xu, Xin-Ya ; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Sun, Yu-Lin] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Zheng, Zhi-Hui] North China Pharmaceutical Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 052260, Hebei, Peoples R China
项目归属: LMB
资助者: 973 Program of China [2010CB833803]; 863 Program of China [2012AA092104]; National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [40931160435, 40976090]; Science and Technology Foundation of Guangdong Province [2010B030600009]
摘要: Three new polyketides penicitrinol G (1), penicitrinol H (2) and 2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone (3) together with one known cathepsin B inhibitor chrysophanol (4) were isolated from a culture broth of marine-derived fungus Penicillium citrinum SCSGAF 0167. Their structures were determined by spectroscopic methods. Compound 4 exhibited inhibitory activity against cathepsin B with IC50 value of 1.7 mu M.
原文出处: 查看原文
WOS记录号: WOS:000333939500004
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10470
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Sun, YL; Zhang, XY; Zheng, ZH; Xu, XY; Qi, SH.Three new polyketides from marine-derived fungus Penicillium citrinum SCSGAF 0167,NATURAL PRODUCT RESEARCH,2014,28(4):239-244
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