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Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208
Ai, W; Lin, XP; Tu, ZC; Tian, XP; Lu, X; Mangaladoss, F; Zhong, ZL; Liu, YH; yonghongliu@scsio.ac.cn
2014
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume28Issue:16Pages:1219-1224
AbstractAxinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 mu M.
Department[Ai, Wen ; Lin, Xiu-Ping ; Tian, Xin-Peng ; Mangaladoss, Fredimoses ; Zhong, Zhi-Long ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Ai, Wen ; Zhong, Zhi-Long] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Tu, Zhengchao ; Lu, Xin] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China
KeywordStreptomyces Axinellae Cox-2 Inhibitor
Subject AreaChemistry ; Pharmacology & Pharmacy
Funding OrganizationNational Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
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Indexed Bysci
Funding ProjectLMB
Funding OrganizationNational Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
WOS IDWOS:000340267000001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10480
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoryonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
Ai, W,Lin, XP,Tu, ZC,et al. Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208[J]. NATURAL PRODUCT RESEARCH,2014,28(16):1219-1224.
APA Ai, W.,Lin, XP.,Tu, ZC.,Tian, XP.,Lu, X.,...&yonghongliu@scsio.ac.cn.(2014).Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208.NATURAL PRODUCT RESEARCH,28(16),1219-1224.
MLA Ai, W,et al."Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208".NATURAL PRODUCT RESEARCH 28.16(2014):1219-1224.
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