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学科主题: Chemistry ; Pharmacology & Pharmacy
题名: Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208
作者: Ai, W ; Lin, XP ; Tu, ZC ; Tian, XP ; Lu, X ; Mangaladoss, F ; Zhong, ZL ; Liu, YH
通讯作者: yonghongliu@scsio.ac.cn
关键词: Streptomyces axinellae ; COX-2 ; inhibitor
刊名: NATURAL PRODUCT RESEARCH
发表日期: 2014
卷: 28, 期:16, 页:1219-1224
收录类别: sci
部门归属: [Ai, Wen ; Lin, Xiu-Ping ; Tian, Xin-Peng ; Mangaladoss, Fredimoses ; Zhong, Zhi-Long ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Ai, Wen ; Zhong, Zhi-Long] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Tu, Zhengchao ; Lu, Xin] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China
项目归属: LMB
资助者: National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
摘要: Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 mu M.
原文出处: 查看原文
WOS记录号: WOS:000340267000001
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10480
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Ai, W; Lin, XP; Tu, ZC; Tian, XP; Lu, X; Mangaladoss, F; Zhong, ZL; Liu, YH.Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208,NATURAL PRODUCT RESEARCH,2014,28(16):1219-1224
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