Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)
Xiang, ZM; Qu, FF; Li, J; Qi, L; Yang, Z; Kong, XY; Yu, ZN; carlzyu@scsio.ac.cn
2014
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
卷号36期号:1页码:83-89
摘要Growing evidence suggests that the transcription factor activator protein-1 (AP-1), a downstream target of mitogen-activated protein kinase (MAPK) signaling, plays a major role in stimulating the synthesis of immune effector molecules during innate immune responses. We have characterized ChAP-1, an AP-1-like protein in Crassostrea hongkongensis that is a member of the AP-1 family of proteins. ChAP-1 is composed of 290 amino acid residues with a Jun and bZIP domain at the N- and C-termini, respectively, a structure similar to that of known Ap-1 proteins. ChAP-1 mRNA is expressed in several tissues analyzed, with highest expression in the mantle. Expression of ChAP-1 increases in response to Vibrio alginolyticus, Salmo haemolyticus or Salmo cerevisiae infection and, despite the location of GFP-tagged full-length ChAP-1 protein in the cytoplasm, ChAP-1 activates the transcription of an L8G5-luc reporter gene, and its overexpression can also activate the AP-1-Luc reporter gene in HEK293T cells. (C) 2013 Elsevier Ltd. All rights reserved.
部门归属[Xiang, Zhiming ; Qu, Fufa ; Li, Jun ; Yang, Zhang ; Kong, Xiaoyu ; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Qu, Fufa ; Li, Jun] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China ; [Qi, Lin] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
关键词Crassostrea Hongkongensis Immunity Chap-1
学科领域Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
资助者National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095] ; National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095] ; National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095] ; National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095]
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收录类别sci
资助项目LMB
资助者National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095] ; National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095] ; National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095] ; National Science Foundation of China [31202021, 31001130, 41176150]; National Basic Research Program of China [2010CB126404]; Program of the Pearl River Young Talents of Science and Technology in Guangzhou, China [2013J2200095]
WOS记录号WOS:000331671600011
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10492
专题中科院海洋生物资源可持续利用重点实验室
通讯作者carlzyu@scsio.ac.cn
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Xiang, ZM,Qu, FF,Li, J,et al. Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)[J]. FISH & SHELLFISH IMMUNOLOGY,2014,36(1):83-89.
APA Xiang, ZM.,Qu, FF.,Li, J.,Qi, L.,Yang, Z.,...&carlzyu@scsio.ac.cn.(2014).Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis).FISH & SHELLFISH IMMUNOLOGY,36(1),83-89.
MLA Xiang, ZM,et al."Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis)".FISH & SHELLFISH IMMUNOLOGY 36.1(2014):83-89.
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