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Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis
Lei, H; Sun, JF; Han, Z; Zhou, XF; Yang, B; Liu, YH; yonghongliu@scsio.ac.cn
2014
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume4Issue:10Pages:5261-5271
AbstractOur continuous study on the South China Sea gorgonian Junceella fragilis led to the isolation of twelve new briarane type diterpenoids, fragilisinins A-L (1-12), along with seven known analogues (13-19), including four naturally produced organoiodides (9-12), they are the first four iodine-containing briarane diterpenoids from this gorgonian species. Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in the literature. The configuration of 1 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 5, 6, 10, 13, and 15 had potent antifouling activities at nontoxic concentrations with EC50 values of 14.0, 12.6, 11.9, 5.6, and 10.0 mu M, respectively.
Department[Lei, Hui ; Sun, Jian-Fan ; Zhou, Xue-Feng ; Yang, Bin ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China ; [Lei, Hui] Chinese Acad Sci, Shanghai Inst Biol Sci, Ind Innovat Ctr Nutr & Hlth Huzhou, Huzhou 313000, Peoples R China ; [Sun, Jian-Fan] Jiangsu Univ, Sch Environm, Zhenjiang 212013, Peoples R China ; [Han, Zhuang] Hong Kong Univ Sci & Technol, Div Life Sci, Sect Marine Ecol & Biotechnol, KAUST Global Acad Partnership Program, Clear Water Bay, Hong Kong, Peoples R China
Subject AreaChemistry
Funding OrganizationNational Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
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Indexed Bysci
Funding ProjectLMB
Funding OrganizationNational Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002] ; National Basic Research Program of China (973 Program) [2010CB833800, 2011CB915503]; National High Technology Research and Development Program (863 Program) [2012AA092104]; National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]; Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
WOS IDWOS:000329254100068
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10498
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoryonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
Lei, H,Sun, JF,Han, Z,et al. Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis[J]. RSC ADVANCES,2014,4(10):5261-5271.
APA Lei, H.,Sun, JF.,Han, Z.,Zhou, XF.,Yang, B.,...&yonghongliu@scsio.ac.cn.(2014).Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis.RSC ADVANCES,4(10),5261-5271.
MLA Lei, H,et al."Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis".RSC ADVANCES 4.10(2014):5261-5271.
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