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Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17
Fang, W; Lin, XP; Zhou, XF; Wan, JT; Lu, X; Yang, B; Ai, W; Lin, J; Zhang, TY; Tu, ZC; Liu, YH; xfzhou@scsio.ac.cn; yonghongliu@scsio.ac.cn
2014
发表期刊MEDCHEMCOMM
ISSN2040-2503
卷号5期号:6页码:701-705
摘要Nitrobenzoyl sesquiterpenoids are rare in natural sources, and fungi Aspergillus species are the only sources of them. A new nitrobenzoyl sesquiterpenoid, 6 beta, 9 alpha-dihydroxy-14-p-nitrobenzoylcinnamolide (1), and a known analogue, insulicolide A (2), were isolated from extracts of the culture of marine-derived fungus Aspergillus ochraceus Jcma1F17, which was identified by morphological and ITS phylogenetic analyses. The structures were determined by NMR, MS, CD, and optical rotation analyses. Both nitrobenzoyl sesquiterpenoids displayed significant cytotoxicities against 10 cancer cell lines, and the new one (1) also showed antiviral activities against H3N2 and EV71. This is the first time that nitrobenzoyl sesquiterpenoids from A. ochraceus have been reported.
部门归属[Fang, Wei] Hubei Acad Agr Sci, Ctr Biopesticide Engn Res, Wuhan 430064, Peoples R China ; [Lin, Xiuping ; Zhou, Xuefeng ; Yang, Bin ; Ai, Wen ; Lin, Ji ; Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol,CAS Key Lab Trop Mar, Guangzhou 510301, Guangdong, Peoples R China
学科领域Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] ; National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] ; National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] ; National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001]
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收录类别sci
资助项目广东省海洋药物重点实验室
资助者National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] ; National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] ; National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] ; National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001]
WOS记录号WOS:000336843000002
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10662
专题广东省海洋药物重点实验室
通讯作者xfzhou@scsio.ac.cn; yonghongliu@scsio.ac.cn
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Fang, W,Lin, XP,Zhou, XF,et al. Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17[J]. MEDCHEMCOMM,2014,5(6):701-705.
APA Fang, W.,Lin, XP.,Zhou, XF.,Wan, JT.,Lu, X.,...&yonghongliu@scsio.ac.cn.(2014).Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17.MEDCHEMCOMM,5(6),701-705.
MLA Fang, W,et al."Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17".MEDCHEMCOMM 5.6(2014):701-705.
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