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Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis
Chen, YL; Zhang, WJ; Zhu, YG; Zhang, QB; Tian, XP; Zhang, S; Zhang, CS; zhuyiguang2003@163.com; czhang2006@gmail.com
2014
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume16Issue:3Pages:736-739
AbstractThe piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4'-hydroxylase and PieB2 as a 4'-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin El (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring.
Department[Chen, Yaolong ; Zhang, Wenjun ; Zhu, Yiguang ; Zhang, Qingbo ; Tian, Xinpeng ; Zhang, Si ; Zhang, Changsheng] Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,Key Lab Trop Mar, Guangzhou 510301, Guangdong, Peoples R China ; [Chen, Yaolong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Subject AreaChemistry
Funding OrganizationMOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
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Indexed Bysci
Funding Project广东省海洋药物重点实验室
Funding OrganizationMOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] ; MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
WOS IDWOS:000331163900025
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10663
Collection广东省海洋药物重点实验室
Corresponding Authorzhuyiguang2003@163.com; czhang2006@gmail.com
Recommended Citation
GB/T 7714
Chen, YL,Zhang, WJ,Zhu, YG,et al. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis[J]. ORGANIC LETTERS,2014,16(3):736-739.
APA Chen, YL.,Zhang, WJ.,Zhu, YG.,Zhang, QB.,Tian, XP.,...&czhang2006@gmail.com.(2014).Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis.ORGANIC LETTERS,16(3),736-739.
MLA Chen, YL,et al."Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis".ORGANIC LETTERS 16.3(2014):736-739.
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