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学科主题: Chemistry
题名: Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis
作者: Chen, YL ; Zhang, WJ ; Zhu, YG ; Zhang, QB ; Tian, XP ; Zhang, S ; Zhang, CS
通讯作者: zhuyiguang2003@163.com ; czhang2006@gmail.com
刊名: ORGANIC LETTERS
发表日期: 2014
卷: 16, 期:3, 页:736-739
收录类别: sci
部门归属: [Chen, Yaolong ; Zhang, Wenjun ; Zhu, Yiguang ; Zhang, Qingbo ; Tian, Xinpeng ; Zhang, Si ; Zhang, Changsheng] Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,Key Lab Trop Mar, Guangzhou 510301, Guangdong, Peoples R China ; [Chen, Yaolong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
项目归属: 广东省海洋药物重点实验室
资助者: MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
摘要: The piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4'-hydroxylase and PieB2 as a 4'-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin El (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring.
原文出处: 查看原文
WOS记录号: WOS:000331163900025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10663
Appears in Collections:广东省海洋药物重点实验室_期刊论文

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Recommended Citation:
Chen, YL; Zhang, WJ; Zhu, YG; Zhang, QB; Tian, XP; Zhang, S; Zhang, CS.Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis,ORGANIC LETTERS,2014,16(3):736-739
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