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学科主题: Plant Sciences ; Pharmacology & Pharmacy
题名: Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
作者: Zhang, WJ ; Li, SM ; Zhu, YG ; Chen, YC ; Chen, YL ; Zhang, HB ; Zhang, GT ; Tian, XP ; Pan, Y ; Zhang, S ; Zhang, WM ; Zhang, CS
通讯作者: czhang2006@gmail.com
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2014
卷: 77, 期:2, 页:388-391
收录类别: sci
部门归属: [Zhang, Wenjun ; Li, Sumei ; Zhu, Yiguang ; Chen, Yaolong ; Zhang, Haibo ; Zhang, Guangtao ; Tian, Xinpeng ; Zhang, Si ; Zhang, Changsheng] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Mcd, RNAM Ctr Marine Microbiol,Key Lab Trop Marine Bio, Guangzhou 510301, Guangdong, Peoples R China ; [Chen, Yuchan ; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China ; [Pan, Yu] Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Guangdong, Peoples R China
项目归属: 广东省海洋药物重点实验室
资助者: Ministry of Science and Technology of China [2012AA092104, 2010CB833805]; Chinese Academy of Sciences [XDA11030403]; National Natural Science Foundation of China [31200039, 31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
摘要: Three new macrolactams, heronamides D-F (1-3), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D-F (1-3) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A-C. The relative configurations of 1-3 were deduced by detailed analysis of (3)J(HH) values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher's method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.
原文出处: 查看原文
WOS记录号: WOS:000332354700027
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10664
Appears in Collections:广东省海洋药物重点实验室_期刊论文

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Recommended Citation:
Zhang, WJ; Li, SM; Zhu, YG; Chen, YC; Chen, YL; Zhang, HB; Zhang, GT; Tian, XP; Pan, Y; Zhang, S; Zhang, WM; Zhang, CS.Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032,JOURNAL OF NATURAL PRODUCTS,2014,77(2):388-391
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