Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus
其他题名mannual of IR
[Huang, Xiaohong; Huang, Youhua; Cai, Jia; Wei, Shina; Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Gao, Ren] Hainan Univ, Coll Marine Sci, State Key Lab, Breeding Base Sustainable Exploitat Trop Biot Res, Haikou 570228, Peoples R China; qinqw@scsio.ac.cn
2013
发表期刊VIRUS RESEARCH
ISSN0168-1702
卷号178期号:2页码:340-348
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摘要Virus encoded tumor necrosis factor receptors (TNFRs) have been demonstrated to facilitate virus to escape from apoptosis or other host immune response for viral replication. Singapore grouper iridovirus (SGIV), a large DNA virus which belongs to genus Ranavirus, is a major pathogen resulting in heavy economic losses to grouper aquaculture. Here, SGIV ORF096 (VP96) encoding a putative homolog of TNFR was identified and characterized. Multiple sequence alignment indicated that SGIV-VP96 contained two extracellular cysteine-rich domains (CRDs) with conserved four or six cysteine residues, but lacked the transmembrane domain at the C-terminus. SGIV-VP96 was identified as an early (E) gene and localized in the cytoplasm in transfected or infected cells. Overexpression of SGIV-VP96 in vitro enhanced cell proliferation, and improved cell survival against SGIV infection. Furthermore, virus infection induced apoptosis and caspase-3 activity were inhibited in SGIV-VP96 expressing FHM cells compared to the control cells. Taken together, our results suggested that SGIV might utilize virus encoded TNFR like genes to modulate the host apoptotic response for effective virus replication. (C) 2013 Elsevier B.V. All rights reserved.; description.abstract
部门归属LMB
关键词Sgiv Ranavirus Vp96 Tnfr Apoptosis Cell Proliferation
学科领域Virology
资助者This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404).
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收录类别sci
语种英语
资助项目description.project
资助者This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404).
WOS记录号WOS:000329266300018
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10943
专题中科院海洋生物资源可持续利用重点实验室
通讯作者qinqw@scsio.ac.cn
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[Huang, Xiaohong,Huang, Youhua,Cai, Jia,et al. Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus[J]. VIRUS RESEARCH,2013,178(2):340-348.
APA [Huang, Xiaohong.,Huang, Youhua.,Cai, Jia.,Wei, Shina.,Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.,...&qinqw@scsio.ac.cn.(2013).Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus.VIRUS RESEARCH,178(2),340-348.
MLA [Huang, Xiaohong,et al."Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus".VIRUS RESEARCH 178.2(2013):340-348.
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