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Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus
Alternative Titlemannual of IR
[Huang, Xiaohong; Huang, Youhua; Cai, Jia; Wei, Shina; Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Gao, Ren] Hainan Univ, Coll Marine Sci, State Key Lab, Breeding Base Sustainable Exploitat Trop Biot Res, Haikou 570228, Peoples R China; qinqw@scsio.ac.cn
2013
Source PublicationVIRUS RESEARCH
ISSN0168-1702
Volume178Issue:2Pages:340-348
Contribution Rank产权排序
Cooperation Status填入合作性质等
AbstractVirus encoded tumor necrosis factor receptors (TNFRs) have been demonstrated to facilitate virus to escape from apoptosis or other host immune response for viral replication. Singapore grouper iridovirus (SGIV), a large DNA virus which belongs to genus Ranavirus, is a major pathogen resulting in heavy economic losses to grouper aquaculture. Here, SGIV ORF096 (VP96) encoding a putative homolog of TNFR was identified and characterized. Multiple sequence alignment indicated that SGIV-VP96 contained two extracellular cysteine-rich domains (CRDs) with conserved four or six cysteine residues, but lacked the transmembrane domain at the C-terminus. SGIV-VP96 was identified as an early (E) gene and localized in the cytoplasm in transfected or infected cells. Overexpression of SGIV-VP96 in vitro enhanced cell proliferation, and improved cell survival against SGIV infection. Furthermore, virus infection induced apoptosis and caspase-3 activity were inhibited in SGIV-VP96 expressing FHM cells compared to the control cells. Taken together, our results suggested that SGIV might utilize virus encoded TNFR like genes to modulate the host apoptotic response for effective virus replication. (C) 2013 Elsevier B.V. All rights reserved.; description.abstract
DepartmentLMB
KeywordSgiv Ranavirus Vp96 Tnfr Apoptosis Cell Proliferation
Subject AreaVirology
Funding OrganizationThis work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404).
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Indexed Bysci
Language英语
Funding Projectdescription.project
Funding OrganizationThis work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404). ; This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404).
WOS IDWOS:000329266300018
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/10943
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorqinqw@scsio.ac.cn
Recommended Citation
GB/T 7714
[Huang, Xiaohong,Huang, Youhua,Cai, Jia,et al. Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus[J]. VIRUS RESEARCH,2013,178(2):340-348.
APA [Huang, Xiaohong.,Huang, Youhua.,Cai, Jia.,Wei, Shina.,Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China.,...&qinqw@scsio.ac.cn.(2013).Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus.VIRUS RESEARCH,178(2),340-348.
MLA [Huang, Xiaohong,et al."Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus".VIRUS RESEARCH 178.2(2013):340-348.
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