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学科主题: Virology
题名: Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus
其他题名: mannual of IR
作者: [Huang, Xiaohong ; Huang, Youhua ; Cai, Jia ; Wei, Shina ; Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Gao, Ren] Hainan Univ, Coll Marine Sci, State Key Lab, Breeding Base Sustainable Exploitat Trop Biot Res, Haikou 570228, Peoples R China
通讯作者: qinqw@scsio.ac.cn
关键词: SGIV ; Ranavirus ; VP96 ; TNFR ; Apoptosis ; Cell proliferation
刊名: VIRUS RESEARCH
发表日期: 2013
卷: 178, 期:2, 页:340-348
收录类别: sci
合作性质: 填入合作性质等
部门归属: LMB
项目归属: description.project
产权排名: 产权排序
资助者: This work was supported by grants from the National Natural Science Foundation of China (30930070, 31172445, 31172437, 30700616) and the National Basic Research Program of China (973) (2012CB114402, 2012CB114404).
摘要: Virus encoded tumor necrosis factor receptors (TNFRs) have been demonstrated to facilitate virus to escape from apoptosis or other host immune response for viral replication. Singapore grouper iridovirus (SGIV), a large DNA virus which belongs to genus Ranavirus, is a major pathogen resulting in heavy economic losses to grouper aquaculture. Here, SGIV ORF096 (VP96) encoding a putative homolog of TNFR was identified and characterized. Multiple sequence alignment indicated that SGIV-VP96 contained two extracellular cysteine-rich domains (CRDs) with conserved four or six cysteine residues, but lacked the transmembrane domain at the C-terminus. SGIV-VP96 was identified as an early (E) gene and localized in the cytoplasm in transfected or infected cells. Overexpression of SGIV-VP96 in vitro enhanced cell proliferation, and improved cell survival against SGIV infection. Furthermore, virus infection induced apoptosis and caspase-3 activity were inhibited in SGIV-VP96 expressing FHM cells compared to the control cells. Taken together, our results suggested that SGIV might utilize virus encoded TNFR like genes to modulate the host apoptotic response for effective virus replication. (C) 2013 Elsevier B.V. All rights reserved.
英文摘要: description.abstract
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000329266300018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10943
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[Huang, Xiaohong; Huang, Youhua; Cai, Jia; Wei, Shina; Qin, Qiwei] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Gao, Ren] Hainan Univ, Coll Marine Sci, State Key Lab, Breeding Base Sustainable Exploitat Trop Biot Res, Haikou 570228, Peoples R China.Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus,VIRUS RESEARCH,2013,178(2):340-348
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文件名: Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus.pdf
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