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学科主题: Multidisciplinary Sciences
题名: miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death
作者: [Guo, Chuanyu ; Yan, Yang ; Huang, Xiaohong ; Qin, Qiwei] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China ; [Guo, Chuanyu] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Cui, Huachun] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
通讯作者: qinqw@scsio.ac.cn
刊名: PLOS ONE
发表日期: 2013
卷: 8, 期:12, 页:-e83027
部门归属: LMB
资助者: This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
摘要: Growing evidence demonstrates that various large DNA viruses could encode microRNAs (miRNAs) that regulate host and viral genes to achieve immune evasion. In this study, we report that miR-homoHSV, an miRNA encoded by Singapore grouper iridovirus (SGIV), can attenuate SGIV-induced cell death. Mechanistically, SGIV miR-homoHSV targets SGIV ORF136R, a viral gene that encodes the pro-apoptotic lipopolysaccharide-induced TNF-alpha (LITAF)-like factor. miR-homoHSV suppressed exogenous and endogenous SGIV LITAF expression, and thus inhibited SGIV LITAF-induced apoptosis. Meanwhile, miR-homoHSV expression was able to attenuate cell death induced by viral infection, presumably facilitating viral replication through the down-regulation of the pro-apoptotic gene SGIV LITAF. Together, our data suggest miR-homoHSV may serve as a feedback regulator of cell death during viral infection. The findings of this study provide a better understanding of SGIV replication and pathogenesis.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000327947800105
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10947
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[Guo, Chuanyu; Yan, Yang; Huang, Xiaohong; Qin, Qiwei] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China; [Guo, Chuanyu] Univ Chinese Acad Sci, Beijing, Peoples R China; [Cui, Huachun] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death,PLOS ONE,2013,8(12):-e83027
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