miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death
[Guo, Chuanyu; Yan, Yang; Huang, Xiaohong; Qin, Qiwei] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China; [Guo, Chuanyu] Univ Chinese Acad Sci, Beijing, Peoples R China; [Cui, Huachun] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA; qinqw@scsio.ac.cn
2013
发表期刊PLOS ONE
ISSN1932-6203
卷号8期号:12页码:-e83027
摘要Growing evidence demonstrates that various large DNA viruses could encode microRNAs (miRNAs) that regulate host and viral genes to achieve immune evasion. In this study, we report that miR-homoHSV, an miRNA encoded by Singapore grouper iridovirus (SGIV), can attenuate SGIV-induced cell death. Mechanistically, SGIV miR-homoHSV targets SGIV ORF136R, a viral gene that encodes the pro-apoptotic lipopolysaccharide-induced TNF-alpha (LITAF)-like factor. miR-homoHSV suppressed exogenous and endogenous SGIV LITAF expression, and thus inhibited SGIV LITAF-induced apoptosis. Meanwhile, miR-homoHSV expression was able to attenuate cell death induced by viral infection, presumably facilitating viral replication through the down-regulation of the pro-apoptotic gene SGIV LITAF. Together, our data suggest miR-homoHSV may serve as a feedback regulator of cell death during viral infection. The findings of this study provide a better understanding of SGIV replication and pathogenesis.
部门归属LMB
学科领域Multidisciplinary Sciences
资助者This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
URL查看原文
语种英语
资助者This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; This work was supported by grants from the National Basic Research Program of China (973) (2012CB114402), the National Natural Science Foundation of China (41206137), the Knowledge Innovative Program of the Chinese Academy of Sciences (SQ201116, KZCX2-EW-Q213). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS记录号WOS:000327947800105
引用统计
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10947
专题中科院海洋生物资源可持续利用重点实验室
通讯作者qinqw@scsio.ac.cn
推荐引用方式
GB/T 7714
[Guo, Chuanyu,Yan, Yang,Huang, Xiaohong,et al. miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death[J]. PLOS ONE,2013,8(12):-e83027.
APA [Guo, Chuanyu.,Yan, Yang.,Huang, Xiaohong.,Qin, Qiwei] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China.,[Guo, Chuanyu] Univ Chinese Acad Sci, Beijing, Peoples R China.,...&qinqw@scsio.ac.cn.(2013).miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death.PLOS ONE,8(12),-e83027.
MLA [Guo, Chuanyu,et al."miR-homoHSV of Singapore Grouper Iridovirus (SGIV) Inhibits Expression of the SGIV Pro-apoptotic Factor LITAF and Attenuates Cell Death".PLOS ONE 8.12(2013):-e83027.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
miR-homoHSV of Singa(2035KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。