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学科主题: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
题名: Cloning, characterization and expression analysis of a caspase-8 like gene from the Hong Kong oyster, Crassostrea hongkongensis
作者: [Xiang, Zhiming ; Qu, Fufa ; Zhang, Yang ; Tong, Ying ; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Qu, Fufa] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Qi, Lin] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
通讯作者: carlzyu@scsio.ac.cn
关键词: Crassostrea hongkongensis ; Apoptosis ; ChCaspase-8 ; NF-kappa B
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2013
卷: 35, 期:6, 页:1797-1803
部门归属: LMB
资助者: This research was supported by the National Science Foundation of China (No. 31202021 and 41176150), a National Basic Research Program of China (No. 2010CB126404) and a Guangdong-NSFC Joint Fund (U1201215). We thank Prof. Elizabeth De Stasio for her editing to the manuscript.
摘要: Apoptosis plays a key role in many biological processes, including homeostasis within the immune system. A family of cysteine proteases, the caspases, constitutes the core of the apoptotic machinery. We have characterized the first bivalve caspase-8 ortholog from the Hong Kong oyster Crassostrea hongkongensis (designated ChCaspase-8). The full-length cDNA is 1945 bp in length encoding a putative protein of 557 amino acids that contains two N-terminal DED domains, and a CASc domain at the C-terminus. ChCaspase-8 is ubiquitously expressed in oysters, with highest expression levels in the gonad and labial palps. Following microbial infection, the expression of ChCaspase-8 increased in hemocytes from 12 to 72 h post-challenge. When expressed in HeLa cells, ChCaspase-8 is located in the cytoplasm, while over-expression of ChCaspase-8 in HEK293T cells activates the transcriptional activities of NF-kappa B. These results indicate that ChCaspase-8 might play an important role in the immune and apoptotic responses of oysters. (C) 2013 Elsevier Ltd. All rights reserved.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000330158800012
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10950
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[Xiang, Zhiming; Qu, Fufa; Zhang, Yang; Tong, Ying; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Qu, Fufa] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Qi, Lin] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China.Cloning, characterization and expression analysis of a caspase-8 like gene from the Hong Kong oyster, Crassostrea hongkongensis,FISH & SHELLFISH IMMUNOLOGY,2013,35(6):1797-1803
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