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学科主题: Chemistry, Medicinal
题名: New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
作者: [Yang, Bin ; Liao, Shengrong ; Lin, Xiuping ; Wang, Junfeng ; Liu, Juan ; Zhou, Xuefeng ; Yang, Xianwen ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Res Ctr Marine Microbes, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: bingo525@163.com ; ljrss@126.com ; xiupinglin@hotmail.com ; junfeng1982a@163.com ; ljuan2010@qq.com ; xfzhou@scsio.ac.cn ; xwyang@scsio.ac.cn ; yonghongliu@scsio.ac.cn
关键词: soft coral ; Sinularia sp ; sesquiterpenes ; sinularianins ; NF-B
刊名: MARINE DRUGS
发表日期: 2013
卷: 11, 期:12, 页:4741-4750
部门归属: LMB
资助者: This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002).
摘要: Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-B activation using the cell-based HEK293 NF-B luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 mu g/mL, respectively.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000330220400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10952
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[Yang, Bin; Liao, Shengrong; Lin, Xiuping; Wang, Junfeng; Liu, Juan; Zhou, Xuefeng; Yang, Xianwen; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Res Ctr Marine Microbes, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China.New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.,MARINE DRUGS,2013,11(12):4741-4750
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