New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.
[Yang, Bin; Liao, Shengrong; Lin, Xiuping; Wang, Junfeng; Liu, Juan; Zhou, Xuefeng; Yang, Xianwen; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Res Ctr Marine Microbes, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China; bingo525@163.com; ljrss@126.com; xiupinglin@hotmail.com; junfeng1982a@163.com; ljuan2010@qq.com; xfzhou@scsio.ac.cn; xwyang@scsio.ac.cn; yonghongliu@scsio.ac.cn
2013
发表期刊MARINE DRUGS
ISSN1660-3397
卷号11期号:12页码:4741-4750
摘要Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-B activation using the cell-based HEK293 NF-B luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 mu g/mL, respectively.
部门归属LMB
关键词Soft Coral Sinularia Sp Sesquiterpenes Sinularianins Nf-b
学科领域Chemistry, Medicinal
资助者This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). ; This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). ; This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). ; This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002).
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语种英语
资助者This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). ; This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). ; This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). ; This study was supported by grants from the National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), National Natural Science Foundation of China (21302198, 31270402, 21172230, 30973679, 41376162 and 41176148), Knowledge Innovation Program of Chinese Academy of Science (SQ201117 and SQ201019), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002).
WOS记录号WOS:000330220400003
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10952
专题中科院海洋生物资源可持续利用重点实验室
通讯作者bingo525@163.com; ljrss@126.com; xiupinglin@hotmail.com; junfeng1982a@163.com; ljuan2010@qq.com; xfzhou@scsio.ac.cn; xwyang@scsio.ac.cn; yonghongliu@scsio.ac.cn
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[Yang, Bin,Liao, Shengrong,Lin, Xiuping,et al. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.[J]. MARINE DRUGS,2013,11(12):4741-4750.
APA [Yang, Bin.,Liao, Shengrong.,Lin, Xiuping.,Wang, Junfeng.,Liu, Juan.,...&yonghongliu@scsio.ac.cn.(2013).New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp..MARINE DRUGS,11(12),4741-4750.
MLA [Yang, Bin,et al."New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.".MARINE DRUGS 11.12(2013):4741-4750.
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