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学科主题: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
题名: Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp SCSIO 10355
作者: [Yang, Xian-Wen ; Peng, Kun ; Zhang, Gai-Yun ; Li, Jie ; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China ; [Yang, Xian-Wen ; Wang, Ning ; Steinmetz, Andre] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg ; [Liu, Zhong] Jinan Univ, Guangzhoujinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
通讯作者: ning.wang@crp-sante.lu ; yonghongliu@scsio.ac.cn
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2013
卷: 76, 期:12, 页:2360-2363
部门归属: LMB
资助者: This study was supported by grants from the National High Technology Research and Development Program of China (863 Program, 2012AA092104), the National Key Basic Research Program of China (2010CB833800, 2011CB915503), National Natural Science Foundation of China (41176148, 21002110, 21372233), and FP7-People-IRSES-2008 (TCMCANCER Project 230232).
摘要: Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S)-4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.0(1,5)]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNF alpha production in RAW264.7 macrophages.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000329331200026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10954
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Yang, Xian-Wen; Peng, Kun; Zhang, Gai-Yun; Li, Jie; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China; [Yang, Xian-Wen; Wang, Ning; Steinmetz, Andre] Luxembourg Publ Res Ctr Hlth CRP SANTE, L-1526 Luxembourg, Luxembourg; [Liu, Zhong] Jinan Univ, Guangzhoujinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China.Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp SCSIO 10355,JOURNAL OF NATURAL PRODUCTS,2013,76(12):2360-2363
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