中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Multidisciplinary Sciences
题名: Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification
作者: [Fan, Wenhong ; Li, Qian ; Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China ; [Zhang, Li] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou, Guangdong, Peoples R China
通讯作者: fanwh@buaa.edu.cn
刊名: PLOS ONE
发表日期: 2013
卷: 8, 期:11, 页:-e78123
部门归属: LMB
资助者: This work was supported by the National Natural Science Foundation of China (51290283), Major Science and Technology Program for Water Pollution Control and Treatment of China (No. 2012ZX07501001), and China's National Basic Research Program (No. 2011CB935700). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
摘要: Zinc Oxide Nanoparticles (ZnO NPs) have attracted increasing concerns because of their widespread use and toxic potential. In this study, Zn accumulations in different tissues (gills, liver, muscle, and gut) of goldfish (Carassius auratus) after exposure to ZnO NPs were studied in comparison with bulk ZnO and Zn2+. And the technique of subcellular partitioning was firstly used on the liver of goldfish to study the hepatic accumulation of ZnO NPs. The results showed that at sublethal Zn concentration (2 mg/L), bioaccumulation in goldfish was tissue-specific and dependent on the exposure materials. Compared with Zn2+, the particles of bulk ZnO and the ZnO NPs appeared to aggregate in the environmentally contacted tissues (gills and gut), rather than transport to the internal tissues (liver and muscle). The subcellular distributions of liver differed for the three exposure treatments. After ZnO NPs exposure, Zn percentage in metal-rich granule (MRG) increased significantly, and after Zn2+ exposure, it increased significantly in the organelles. Metallothionein-like proteins (MTLP) were the main target for Zn2+, while MRG played dominant role for ZnO NPs. The different results of subcellular distributions revealed that metal detoxification mechanisms of liver for ZnO NPs, bulk ZnO, and Zn2+ were different. Overall, subcellular partitioning provided an interesting start to better understanding of the toxicity of nano-and conventional materials.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000326499300024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10970
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification.pdf(542KB)----开放获取View Download

Recommended Citation:
[Fan, Wenhong; Li, Qian; Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China; [Zhang, Li] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou, Guangdong, Peoples R China.Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification,PLOS ONE,2013,8(11):-e78123
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[[Fan, Wenhong]'s Articles
[Li, Qian]'s Articles
[Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[[Fan, Wenhong]‘s Articles
[Li, Qian]‘s Articles
[Yang, Xiuping] Beihang Univ, Sch Chem & Environm, Dept Environm Sci & Engn, Beijing, Peoples R China]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Zn Subcellular Distribution in Liver of Goldfish (Carassius Auratus) with Exposure to Zinc Oxide Nanoparticles and Mechanism of Hepatic Detoxification.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace