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学科主题: Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
题名: Transferrin-Modified Doxorubicin-Loaded Biodegradable Nanoparticles Exhibit Enhanced Efficacy in Treating Brain Glioma-Bearing Rats
作者: [Liu, Guodong ; Dong, Jun ; Huang, Qiang ; Lan, Qing] Soochow Univ, Affiliated Hosp 2, Dept Neurosurg, Suzhou 215004, Peoples R China ; [Mao, Jinning] Soochow Univ, Affiliated Hosp 2, Cardiovasc Dept, Suzhou 215004, Peoples R China ; [Jiang, Zirong] Changyi Peoples Hosp, Changyi, Peoples R China ; [Sun, Tao] Xian Jiaotong Liverpool Univ, Dept Biol Sci, Suzhou, Peoples R China ; [Hu, Yunfeng] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China ; [Jiang, Zhen ; Zhang, Caiyuan] Soochow Univ, Affiliated Hosp 2, Dept Radiol, Suzhou 215004, Peoples R China
通讯作者: lanqingsci@163.com
关键词: chemotherapy ; doxorubicin ; glioma ; nanoparticle ; transferrin
刊名: CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
发表日期: 2013
卷: 28, 期:9, 页:691-696
部门归属: LMB
资助者: This work was supported by the University Graduate Students' Scientific Research Innovative Program of Jiangsu Province, China (CX10B-0502) and the National Science Foundation of People's Republic of China (81272799, 81271554).
摘要: Doxorubicin (Dox) is widely used for the treatment of solid tumors but its clinical utility on glioma is limited. In this study, we developed a novel nano-scale drug delivery system employing biodegradable nanoparticle (NP) as carriers to load Dox. Transferrin (Tf) was conjugated to the surface of NP to specifically target the NP to glioma. Tf-NP-Dox was prepared via emulsification-solvent evaporation method, and characterized for the size, Drug loading capacity (DLC), entrapment efficiency, and Tf number on the surface. The antitumor efficiency in vitro was evaluated via CCK-8 assay. The transmembrane transportation was evaluated via HPLC assay. The antitumor efficiency in vivo was assessed in C6 glioma intracranial implant rat model. The average diameter of Tf-NP-Dox was 100nm with approximate to 32 Tf molecules on the surface. DLC was 4.4%. CCK-8 assay demonstrated much stronger cytotoxicity of Tf-NP-Dox to C6 glioma cells compared to NP-Dox or Dox. HPLC assay showed that Tf-NP-Dox transported Dox into C6 cells with high efficiency. In vivo, Tf-NP-Dox could transport Dox into tumors compare to contralateral part, with tumor inhibitory ratio and survival higher than NP-Dox or Dox. Taken together, our results suggest that Tf-NP-Dox exhibits better therapeutic effects against glioma both in vitro and in vivo, and is a potential nano-scale drug delivery system for glioma chemotherapy.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000325267700007
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10972
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Liu, Guodong; Dong, Jun; Huang, Qiang; Lan, Qing] Soochow Univ, Affiliated Hosp 2, Dept Neurosurg, Suzhou 215004, Peoples R China; [Mao, Jinning] Soochow Univ, Affiliated Hosp 2, Cardiovasc Dept, Suzhou 215004, Peoples R China; [Jiang, Zirong] Changyi Peoples Hosp, Changyi, Peoples R China; [Sun, Tao] Xian Jiaotong Liverpool Univ, Dept Biol Sci, Suzhou, Peoples R China; [Hu, Yunfeng] Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China; [Jiang, Zhen; Zhang, Caiyuan] Soochow Univ, Affiliated Hosp 2, Dept Radiol, Suzhou 215004, Peoples R China.Transferrin-Modified Doxorubicin-Loaded Biodegradable Nanoparticles Exhibit Enhanced Efficacy in Treating Brain Glioma-Bearing Rats,CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2013,28(9):691-696
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