Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum
[Sun, Yu-Lin; Bao, Jie; Zhang, Xiao-Yong; He, Fei; Nong, Xu-Hua; Qi, Shu-Hua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Kai-Sheng; Wang, Yi-Fei] Jinan Univ, Guangzhou, Guangdong, Peoples R China; Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; shuhuaqi@scsio.ac.cn
2013
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号79期号:15页码:1474-1479
摘要Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium oxalicum. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 and 2 were established by using the modified Mosher ester method and circular dichroism data of an in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complex. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 was discussed.
部门归属LMB
关键词Penicillium Oxalicum Trichocomaceae Dihydrothiophene-condensed Chromone Cytotoxicity
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B). ; This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B). ; This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B). ; This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B).
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语种英语
资助者This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B). ; This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B). ; This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B). ; This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B).
WOS记录号WOS:000330724200014
引用统计
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/10978
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
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GB/T 7714
[Sun, Yu-Lin,Bao, Jie,Zhang, Xiao-Yong,et al. Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum[J]. PLANTA MEDICA,2013,79(15):1474-1479.
APA [Sun, Yu-Lin.,Bao, Jie.,Zhang, Xiao-Yong.,He, Fei.,Nong, Xu-Hua.,...&shuhuaqi@scsio.ac.cn.(2013).Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum.PLANTA MEDICA,79(15),1474-1479.
MLA [Sun, Yu-Lin,et al."Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum".PLANTA MEDICA 79.15(2013):1474-1479.
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