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学科主题: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
题名: Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum
作者: [Sun, Yu-Lin ; Bao, Jie ; Zhang, Xiao-Yong ; He, Fei ; Nong, Xu-Hua ; Qi, Shu-Hua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Liu, Kai-Sheng ; Wang, Yi-Fei] Jinan Univ, Guangzhou, Guangdong, Peoples R China ; [Sun, Yu-Lin ; Bao, Jie ; Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
通讯作者: shuhuaqi@scsio.ac.cn
关键词: Penicillium oxalicum ; Trichocomaceae ; dihydrothiophene-condensed chromone ; cytotoxicity
刊名: PLANTA MEDICA
发表日期: 2013
卷: 79, 期:15, 页:1474-1479
部门归属: LMB
资助者: This work was financed by grants from NBRPC (973 Program, 2010CB833803), NMPWRPC (grant 201305017), NHTRDPC (863 Program, 2012AA092104), NSFC (40931160435, 40976090, 20872151), and CAS (KSCX2-EW-G-12B).
摘要: Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium oxalicum. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 and 2 were established by using the modified Mosher ester method and circular dichroism data of an in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complex. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 was discussed.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000330724200014
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10978
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Sun, Yu-Lin; Bao, Jie; Zhang, Xiao-Yong; He, Fei; Nong, Xu-Hua; Qi, Shu-Hua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Kai-Sheng; Wang, Yi-Fei] Jinan Univ, Guangzhou, Guangdong, Peoples R China; [Sun, Yu-Lin; Bao, Jie; Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China.Cytotoxic Dihydrothiophene-Condensed Chromones from the Marine-Derived Fungus Penicillium oxalicum,PLANTA MEDICA,2013,79(15):1474-1479
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