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学科主题: Fisheries ; Marine & Freshwater Biology
题名: Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata
作者: [Shi, Yu ; Guan, Yunyan ; He, Maoxian] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: hmx@scsio.ac.cn
关键词: Insulin-related peptide receptor ; PQ401 ; Insulin-like growth factor-I ; Development ; Pinctada fucata
刊名: AQUACULTURE
发表日期: 2013
卷: 408, 页:118-127
部门归属: LMB
资助者: We thank Mr. Manhong Wang for valuable assistance in rearing the oysters and Qi Wang for assistance in collecting samples. This project was supported by the National Natural Science Foundation of China (41176145), the Joint Program of NSFC-Guangdong (U0831001), and the Funds of Knowledge Innovation Program of the Chinese Academy of Sciences (ZCX2-EW-Q21).
摘要: The insulin-like family is not only an important regulatory factor for animal growth, development, and metabolism, but also a mediator for initiating growth activity of growth hormone. It plays an important role in transferring transmembrane information and regulating cell function by binding to tyrosine kinase receptors (insulin receptors). To better understand the role of insulin-related peptide receptor (Pfirr) on the developmental regulation in Pinctada fucata, 5.326 kb encoding cDNAs for Pfirr have been cloned and functionally characterized. Pfirr displays significant homologies to Crassostrea gigas, and exhibits all the typical features of insulin receptors and tyrosine kinase domain structure, both of which are typical for the protein family sharing high similarity to other orthologs. Real-time PCR analyses show that Pfirr widely expresses in tissues and developmental stages of P. fucata. Expression of Pfirr mRNAs at different developmental stages (polar body stage, the trocophore stage and D-shaped larva stage) following treatment with agonist IGF-I(1, 2, 4 and 8 mu M/L) and antagonist PQ401 (5, 15, 25, 50 and 100 mu M/L) indicated that Pfirr may be involved in regulating the development of embryos in P. fucata. These results clearly demonstrate Pfirr is involved in regulating developmental process in P. fucata. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000323554900016
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/10985
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Shi, Yu; Guan, Yunyan; He, Maoxian] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata,AQUACULTURE,2013,408():118-127
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