Two New Compounds from Gorgonian-associated Fungus Aspergillus sp.
[Xu, Xin-Ya; Zhang, Xiao-Yong; He, Fei; Peng, Jiang; Nong, Xu-Hua; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Peng, Jiang; Nong, Xu-Hua] Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; shuhuaqi@scsio.ac.cn
2013
发表期刊NATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
卷号8期号:8页码:1069-1070
摘要One new gamma-lactone derivative 5-hydroxy-3-isopropyl-4-methoxyfuranone (1) and one new lactam derivative dehydrated-marinamide (2), along with two known compounds marinamide (3) and marinamide methyl ester (4) were isolated from the fermentation broth of the marine gorgonian-associated fungus Aspergillus sp. SCSGAF0093. Their structures were elucidated on the basis of spectroscopic and spectrometric analysis. Compound 1 showed significant toxicity to brine shrimp (Artemia sauna) with a median lethal concentration (LC50) of 1.25 mu M, and 3 inhibited protein tyrosine phosphatase 1B (PTPIB) with a half maximal inhibitory concentration (IC50) of 23.3 mu g/mL.
部门归属LMB
关键词Gorgonian-associated Fungus ASp.rgillus Sp. Gamma-lactone Lactam
学科领域Chemistry, Medicinal ; Food Science & Technology
资助者The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support. ; The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support. ; The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support. ; The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support.
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语种英语
资助者The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support. ; The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support. ; The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support. ; The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support.
WOS记录号WOS:000323687500007
引用统计
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11000
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
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GB/T 7714
[Xu, Xin-Ya,Zhang, Xiao-Yong,He, Fei,et al. Two New Compounds from Gorgonian-associated Fungus Aspergillus sp.[J]. NATURAL PRODUCT COMMUNICATIONS,2013,8(8):1069-1070.
APA [Xu, Xin-Ya.,Zhang, Xiao-Yong.,He, Fei.,Peng, Jiang.,Nong, Xu-Hua.,...&shuhuaqi@scsio.ac.cn.(2013).Two New Compounds from Gorgonian-associated Fungus Aspergillus sp..NATURAL PRODUCT COMMUNICATIONS,8(8),1069-1070.
MLA [Xu, Xin-Ya,et al."Two New Compounds from Gorgonian-associated Fungus Aspergillus sp.".NATURAL PRODUCT COMMUNICATIONS 8.8(2013):1069-1070.
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