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学科主题: Chemistry, Medicinal ; Food Science & Technology
题名: Two New Compounds from Gorgonian-associated Fungus Aspergillus sp.
作者: [Xu, Xin-Ya ; Zhang, Xiao-Yong ; He, Fei ; Peng, Jiang ; Nong, Xu-Hua ; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China ; [Peng, Jiang ; Nong, Xu-Hua] Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
通讯作者: shuhuaqi@scsio.ac.cn
关键词: Gorgonian-associated fungus ; Aspergillus sp. ; gamma-Lactone ; Lactam
刊名: NATURAL PRODUCT COMMUNICATIONS
发表日期: 2013
卷: 8, 期:8, 页:1069-1070
部门归属: LMB
资助者: The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support.
摘要: One new gamma-lactone derivative 5-hydroxy-3-isopropyl-4-methoxyfuranone (1) and one new lactam derivative dehydrated-marinamide (2), along with two known compounds marinamide (3) and marinamide methyl ester (4) were isolated from the fermentation broth of the marine gorgonian-associated fungus Aspergillus sp. SCSGAF0093. Their structures were elucidated on the basis of spectroscopic and spectrometric analysis. Compound 1 showed significant toxicity to brine shrimp (Artemia sauna) with a median lethal concentration (LC50) of 1.25 mu M, and 3 inhibited protein tyrosine phosphatase 1B (PTPIB) with a half maximal inhibitory concentration (IC50) of 23.3 mu g/mL.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000323687500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11000
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Xu, Xin-Ya; Zhang, Xiao-Yong; He, Fei; Peng, Jiang; Nong, Xu-Hua; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Peng, Jiang; Nong, Xu-Hua] Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China.Two New Compounds from Gorgonian-associated Fungus Aspergillus sp.,NATURAL PRODUCT COMMUNICATIONS,2013,8(8):1069-1070
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