Thaixylomolins A-C: Limonoids Featuring Two New Motifs from the Thai Xylocarpus moluccensis
[Li, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Li, Min-Yi; Wu, Jun] Jinan Univ, Coll Pharm, Marine Drugs Res Ctr, Guangzhou 510632, Guangdong, Peoples R China; [Bruhn, Torsten; Katele, Felix Zongwe; Bringmann, Gerhard] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany; [Xiao, Qiang] Jiangxi Sci & Technol Normal Univ, Inst Organ Chem, Nanchang 330013, Peoples R China; [Pedpradab, Patchara] Rajamangala Univ Technol Srivijaya, Dept Marine Sci, Fac Sci & Fishery Technol, Songkhla 92150, Trang Province, Thailand; [Li, Jun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; wwujun2003@yahoo.com; bringmann@chemie.uni-wuerzburg.de
2013
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号15期号:14页码:3682-3685
摘要Three limonoids named thaixylomolins A-C (1-3), featuring two new motifs, were isolated from the seeds of a Thai mangrove, Xylocarpus moluccensis. The absolute configurations of these limonoids were determined by extensive NMR investigations, single-crystal X-ray diffraction analysis, and circular-dichroism spectroscopy in combination with quantum-chemical calculations. Thaixylomolin B exhibited inhibitory activity against nitric oxide production in lipopolysaccharide and IFN-gamma-induced RAW264.7 murine macrophages with an IC50 value of 84.3 mu M.
部门归属LMB
学科领域Chemistry, Organic
资助者This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship. ; This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship. ; This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship. ; This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship.
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资助者This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship. ; This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship. ; This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship. ; This work was supported by NSFC (31100258, 31170331, and 81125022), the Guangdong Key Science and Technology Special Project (2011A080403020), and the Deutsche Forschungsge-meinschaft (SFB 630, "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases"). F.Z.K. is grateful to the BEBUC Scholarship System for a fellowship.
WOS记录号WOS:000322210600050
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11007
专题中科院海洋生物资源可持续利用重点实验室
通讯作者wwujun2003@yahoo.com; bringmann@chemie.uni-wuerzburg.de
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[Li, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China,[Li, Min-Yi,Wu, Jun] Jinan Univ, Coll Pharm, Marine Drugs Res Ctr, Guangzhou 510632, Guangdong, Peoples R China,et al. Thaixylomolins A-C: Limonoids Featuring Two New Motifs from the Thai Xylocarpus moluccensis[J]. ORGANIC LETTERS,2013,15(14):3682-3685.
APA [Li, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.,[Li, Min-Yi.,Wu, Jun] Jinan Univ, Coll Pharm, Marine Drugs Res Ctr, Guangzhou 510632, Guangdong, Peoples R China.,[Bruhn, Torsten.,Katele, Felix Zongwe.,...&bringmann@chemie.uni-wuerzburg.de.(2013).Thaixylomolins A-C: Limonoids Featuring Two New Motifs from the Thai Xylocarpus moluccensis.ORGANIC LETTERS,15(14),3682-3685.
MLA [Li, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China,et al."Thaixylomolins A-C: Limonoids Featuring Two New Motifs from the Thai Xylocarpus moluccensis".ORGANIC LETTERS 15.14(2013):3682-3685.
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