Knowledge Management System Of South China Sea Institute of Oceanology,CAS
| Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety | |
| [Zhang, Yun; Huang, Hongbo; Chen, Qi; Luo, Minghe; Sun, Aijun; Song, Yongxiang; Ma, Junying; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; jju@scsio.ac.cn | |
| 2013 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 15Issue:13Pages:3254-3257 |
| Abstract | The gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded P-1894B (1b) as a predominant product. The Delta gcnQ mutant accumulates intermediate la and two shunt products 2a and 3a bearing L-rhodinose for L-cinerulose A substitutions. In vitro data demonstrated that GcnQ is capable of iteratively tailoring the two L-rhodinose moieties into L-aculose moieties, supporting divergent roles of GcnQ in different hosts. |
| Department | LMB |
| Subject Area | Chemistry, Organic |
| Funding Organization | This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). |
| URL | 查看原文 |
| Language | 英语 |
| Funding Organization | This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). |
| WOS ID | WOS:000321605800016 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.scsio.ac.cn/handle/344004/11008 |
| Collection | 中科院海洋生物资源可持续利用重点实验室 |
| Corresponding Author | jju@scsio.ac.cn |
| Recommended Citation GB/T 7714 | [Zhang, Yun,Huang, Hongbo,Chen, Qi,et al. Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety[J]. ORGANIC LETTERS,2013,15(13):3254-3257. |
| APA | [Zhang, Yun.,Huang, Hongbo.,Chen, Qi.,Luo, Minghe.,Sun, Aijun.,...&jju@scsio.ac.cn.(2013).Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety.ORGANIC LETTERS,15(13),3254-3257. |
| MLA | [Zhang, Yun,et al."Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety".ORGANIC LETTERS 15.13(2013):3254-3257. |
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