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Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety
[Zhang, Yun; Huang, Hongbo; Chen, Qi; Luo, Minghe; Sun, Aijun; Song, Yongxiang; Ma, Junying; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; jju@scsio.ac.cn
2013
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume15Issue:13Pages:3254-3257
AbstractThe gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded P-1894B (1b) as a predominant product. The Delta gcnQ mutant accumulates intermediate la and two shunt products 2a and 3a bearing L-rhodinose for L-cinerulose A substitutions. In vitro data demonstrated that GcnQ is capable of iteratively tailoring the two L-rhodinose moieties into L-aculose moieties, supporting divergent roles of GcnQ in different hosts.
DepartmentLMB
Subject AreaChemistry, Organic
Funding OrganizationThis work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004).
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Language英语
Funding OrganizationThis work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004). ; This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004).
WOS IDWOS:000321605800016
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Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11008
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorjju@scsio.ac.cn
Recommended Citation
GB/T 7714
[Zhang, Yun,Huang, Hongbo,Chen, Qi,et al. Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety[J]. ORGANIC LETTERS,2013,15(13):3254-3257.
APA [Zhang, Yun.,Huang, Hongbo.,Chen, Qi.,Luo, Minghe.,Sun, Aijun.,...&jju@scsio.ac.cn.(2013).Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety.ORGANIC LETTERS,15(13),3254-3257.
MLA [Zhang, Yun,et al."Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety".ORGANIC LETTERS 15.13(2013):3254-3257.
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