学科主题: Chemistry, Organic
题名: Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety 作者: [Zhang, Yun
; Huang, Hongbo
; Chen, Qi
; Luo, Minghe
; Sun, Aijun
; Song, Yongxiang
; Ma, Junying
; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: jju@scsio.ac.cn
刊名: ORGANIC LETTERS
发表日期: 2013
卷: 15, 期: 13, 页: 3254-3257 部门归属: LMB
资助者: This work was supported by MOST (2012AA092104, 2010CB833805), NSFC (31290233, 41106138), and STPPGP (2011B031200004).
摘要: The gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded P-1894B (1b) as a predominant product. The Delta gcnQ mutant accumulates intermediate la and two shunt products 2a and 3a bearing L-rhodinose for L-cinerulose A substitutions. In vitro data demonstrated that GcnQ is capable of iteratively tailoring the two L-rhodinose moieties into L-aculose moieties, supporting divergent roles of GcnQ in different hosts. 语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000321605800016
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11008
Appears in Collections: 中科院海洋生物资源可持续利用重点实验室_期刊论文
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[Zhang, Yun; Huang, Hongbo; Chen, Qi; Luo, Minghe; Sun, Aijun; Song, Yongxiang; Ma, Junying; Ju, Jianhua] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Marine Bioresources Sustainable Utili, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety,ORGANIC LETTERS,2013,15(13):3254-3257
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