中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Biochemistry & Molecular Biology ; Plant Sciences
题名: Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius
作者: [Bringmann, Gerhard ; Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany ; [Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany ; [Stich, August] Med Mission Inst, D-97074 Wurzburg, Germany ; [Wu, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China ; [Chatterjee, Manik] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, Dept Internal Med 2, D-97078 Wurzburg, Germany ; [Brun, Reto] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland ; [Brun, Reto] Univ Basel, CH-4003 Basel, Switzerland
通讯作者: bringman@chemie.uni-wuerzburg.de
关键词: Ancistrocladus tectorius ; Ancistrocladaceae ; Naphthylisoquinoline alkaloids ; Structural elucidation ; Anti-parasitic activity
刊名: PHYTOCHEMISTRY
发表日期: 2013
卷: 91, 页:220-228
部门归属: LMB
资助者: This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius.
摘要: Naphthylisoquinoline alkaloids, named ancistectorine A(1), N-methylancistectorine A(1), ancistectorine A(2), 5-epi-ancistectorine A(2), ancistectorine A(3), ancistectorine B-1, and ancistectorine C-1, have been isolated from twigs of the Chinese plant Ancistrocladus tectorius. The structural elucidation succeeded by chemical, spectroscopic, and chiroptical methods. Three of these compounds exhibited excellent, and specific, anti-plasmodial activities, comparable with that of the as yet most active representative, dioncophylline C. Moreover, the antitumoral activities of two of the main alkaloids in this species was tested. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000321727100023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11010
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius.pdf(529KB)----开放获取View Download

Recommended Citation:
[Bringmann, Gerhard; Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany; [Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany; [Stich, August] Med Mission Inst, D-97074 Wurzburg, Germany; [Wu, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Chatterjee, Manik] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, Dept Internal Med 2, D-97078 Wurzburg, Germany; [Brun, Reto] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland; [Brun, Reto] Univ Basel, CH-4003 Basel, Switzerland.Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius,PHYTOCHEMISTRY,2013,91():220-228
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[[Bringmann, Gerhard]'s Articles
[Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany]'s Articles
[[Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[[Bringmann, Gerhard]‘s Articles
[Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany]‘s Articles
[[Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace