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Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius
[Bringmann, Gerhard; Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany; [Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany; [Stich, August] Med Mission Inst, D-97074 Wurzburg, Germany; [Wu, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Chatterjee, Manik] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, Dept Internal Med 2, D-97078 Wurzburg, Germany; [Brun, Reto] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland; [Brun, Reto] Univ Basel, CH-4003 Basel, Switzerland; bringman@chemie.uni-wuerzburg.de
2013
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume91Pages:220-228
AbstractNaphthylisoquinoline alkaloids, named ancistectorine A(1), N-methylancistectorine A(1), ancistectorine A(2), 5-epi-ancistectorine A(2), ancistectorine A(3), ancistectorine B-1, and ancistectorine C-1, have been isolated from twigs of the Chinese plant Ancistrocladus tectorius. The structural elucidation succeeded by chemical, spectroscopic, and chiroptical methods. Three of these compounds exhibited excellent, and specific, anti-plasmodial activities, comparable with that of the as yet most active representative, dioncophylline C. Moreover, the antitumoral activities of two of the main alkaloids in this species was tested. (C) 2012 Elsevier Ltd. All rights reserved.
DepartmentLMB
KeywordAncistrocladus Tectorius Ancistrocladaceae Naphthylisoquinoline Alkaloids Structural Elucidation Anti-parasitic Activity
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
Funding OrganizationThis work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. ; This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. ; This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. ; This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius.
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Language英语
Funding OrganizationThis work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. ; This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. ; This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius. ; This work was supported by the Deutsche Forschungsgemeinschaft (Br 699/14-2; SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases", Projects A2, B3, and Z1, and KFO 216 "Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies"). G.L. Zhang has been supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Wurzburg. We thank Dr. M. Buchner and F. Dadrich for the mass spectra, Dr. M. Grune and E. Ruckdeschel for the NMR experiments, and M. Michel for the degradation experiments. We thank Dr. M.J. Xu for previous work on the crude extract of A. tectorius.
WOS IDWOS:000321727100023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11010
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorbringman@chemie.uni-wuerzburg.de
Recommended Citation
GB/T 7714
[Bringmann, Gerhard,Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany,[Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany,et al. Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius[J]. PHYTOCHEMISTRY,2013,91:220-228.
APA [Bringmann, Gerhard.,Zhang, Guoliang] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany.,[Oelschlaeger, Tobias] Inst Mol Infect Biol, D-97080 Wurzburg, Germany.,[Stich, August] Med Mission Inst, D-97074 Wurzburg, Germany.,[Wu, Jun] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.,...&bringman@chemie.uni-wuerzburg.de.(2013).Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius.PHYTOCHEMISTRY,91,220-228.
MLA [Bringmann, Gerhard,et al."Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius".PHYTOCHEMISTRY 91(2013):220-228.
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