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学科主题: Chemistry, Medicinal
题名: Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp SCSIO 10428
作者: [Wu, Zhengchao ; Li, Sumei ; Li, Jie ; Saurav, Kumar ; Zhang, Qingbo ; Zhang, Haibo ; Zhang, Wenjun ; Zhang, Si ; Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol,Guangdong Key Lab Ma, Guangzhou 510301, Guangdong, Peoples R China ; [Wu, Zhengchao ; Zhang, Qingbo] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Chen, Yuchan ; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
通讯作者: charleszcwu@gmail.com ; lism@scsio.ac.cn ; lijietaren@scsio.ac.cn ; yuchan2006@126.com ; sauravverma17@gmail.com ; gudaobo@163.com ; zhanghb@scsio.ac.cn ; wenjunzha@gmail.com ; wmzhang58@yahoo.com.cn ; zhsimd@scsio.ac.cn ; czhang2006@gmail.com
关键词: napyradiomycins ; marine actinomycetes ; natural products ; antibacterial ; cytotoxicity
刊名: MARINE DRUGS
发表日期: 2013
卷: 11, 期:6, 页:2113-2125
部门归属: LMB
资助者: This work is supported in part by grants from the National Science Foundation of China (31125001), the Funds of the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the funds from Ministry of Science and Technology of China (2010CB833805 and 2012AA092104). C. Z. is a scholar of the "100 Talents Project" of Chinese Academy of Sciences (08SL111002). We are grateful to analytical facility of South China Sea Institute of Oceanology.
摘要: Three new napyradiomycins (1-3) were isolated from the culture broth of a marine-derived actinomycete strain SCSIO 10428, together with six known related analogues napyradiomycin A1 (4), 18-oxonapyradiomycin A1 (5), napyradiomycin B1 (6), napyradiomycin B3 (7), naphthomevalin (8), and napyradiomycin SR (9). The strain SCSIO 10428 was identified as a Streptomyces species by the sequence analysis of its 16S rRNA gene. The structures of new compounds 1-3, designated 4-dehydro-4a-dechlorona pyradiomycin A1 (1), 3-dechloro-3-bromonapyradiomycin A1 (2), and 3-chloro-6, 8-dihydroxy-8-a-lapachone (3), respectively, were elucidated by comparing their 1D and 2D NMR spectroscopic data with known congeners. None of the napyradiomycins 1-9 showed antioxidative activities. Napyradiomycins 1-8 displayed antibacterial activities against three Gram-positive bacteria Staphylococcus and Bacillus strains with MIC values ranging from 0.25 to 32 mu g mL(-1), with the exception that compound 3 had a MIC value of above 128 mu g mL(-1) against Staphylococcus aureus ATCC 29213. Napyradiomycins 2, 4, 6, and 7 exhibited moderate cytotoxicities against four human cancer cell lines SF-268, MCF-7, NCI-H460, and HepG-2 with IC50 values below 20 mu M, while the IC50 values for other five napyradiomycins 1, 3, 5, 8 and 9 were above 20 mu M.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000320772100020
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11018
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[Wu, Zhengchao; Li, Sumei; Li, Jie; Saurav, Kumar; Zhang, Qingbo; Zhang, Haibo; Zhang, Wenjun; Zhang, Si; Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol,Guangdong Key Lab Ma, Guangzhou 510301, Guangdong, Peoples R China; [Wu, Zhengchao; Zhang, Qingbo] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China.Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp SCSIO 10428,MARINE DRUGS,2013,11(6):2113-2125
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