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学科主题: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
题名: Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162
作者: [He, Fei ; Bao, Jie ; Zhang, Xiao-Yong ; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China ; [Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China ; [Shi, Yi-Ming] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China
通讯作者: shuhuaqi@scsio.ac.cn
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2013
卷: 76, 期:6, 页:1182-1186
部门归属: LMB
资助者: The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China.
摘要: A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000321320600026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11019
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[He, Fei; Bao, Jie; Zhang, Xiao-Yong; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China; [Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Shi, Yi-Ming] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China.Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162,JOURNAL OF NATURAL PRODUCTS,2013,76(6):1182-1186
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文件名: Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.pdf
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