SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162
[He, Fei; Bao, Jie; Zhang, Xiao-Yong; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China; [Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Shi, Yi-Ming] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China; shuhuaqi@scsio.ac.cn
2013
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume76Issue:6Pages:1182-1186
AbstractA new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
DepartmentLMB
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Funding OrganizationThe authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China.
URL查看原文
Language英语
Funding OrganizationThe authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China.
WOS IDWOS:000321320600026
Citation statistics
Cited Times:70[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11019
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshuhuaqi@scsio.ac.cn
Recommended Citation
GB/T 7714
[He, Fei,Bao, Jie,Zhang, Xiao-Yong,et al. Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1182-1186.
APA [He, Fei.,Bao, Jie.,Zhang, Xiao-Yong.,Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China.,[Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China.,...&shuhuaqi@scsio.ac.cn.(2013).Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.JOURNAL OF NATURAL PRODUCTS,76(6),1182-1186.
MLA [He, Fei,et al."Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1182-1186.
Files in This Item:
File Name/Size DocType Version Access License
Asperterrestide A, a(865KB) 开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.