Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162
[He, Fei; Bao, Jie; Zhang, Xiao-Yong; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China; [Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Shi, Yi-Ming] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China; shuhuaqi@scsio.ac.cn
2013
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:6页码:1182-1186
摘要A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
部门归属LMB
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China.
URL查看原文
语种英语
资助者The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China. ; The authors are grateful to the National Basic Research Program of China (973 Program, grant 2010CB833803), National Natural Science Foundation of China (grant 41206130), National High Technology Research and Development Program of China (863 Program, grant 2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and Chinese Academy of Sciences (grant 5060267) for financial support. The calculation sections were supported by HPC Center of Kunming Institute of Botany, CAS, China.
WOS记录号WOS:000321320600026
引用统计
被引频次:57[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11019
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
推荐引用方式
GB/T 7714
[He, Fei,Bao, Jie,Zhang, Xiao-Yong,et al. Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1182-1186.
APA [He, Fei.,Bao, Jie.,Zhang, Xiao-Yong.,Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China.,[Tu, Zheng-Chao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China.,...&shuhuaqi@scsio.ac.cn.(2013).Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.JOURNAL OF NATURAL PRODUCTS,76(6),1182-1186.
MLA [He, Fei,et al."Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1182-1186.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Asperterrestide A, a(865KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。