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学科主题: Chemistry, Medicinal
题名: Polyketides from a Marine-Derived Fungus Xylariaceae sp.
作者: [Nong, Xu-Hua ; Zhang, Xiao-Yong ; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Nong, Xu-Hua] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Zheng, Zhi-Hui ; Lu, Xin-Hua] North China Pharmaceutical Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 052260, Hebei, Peoples R China
通讯作者: nongxuhua4883@163.com ; z_zhihui2003@yahoo.com.cn ; zhangxiaoyong@scsio.ac.cn ; luxinhua@ncpcrd.com.cn ; shuhuaqi@scsio.ac.cn
关键词: Xylariaceae sp. ; polyketide ; enzyme-inhibitory activity ; antifouling activity
刊名: MARINE DRUGS
发表日期: 2013
卷: 11, 期:5, 页:1718-1727
部门归属: LMB
资助者: The authors are grateful to 973 Program of China (2010CB833803), 863 Program of China (2012AA092104), National Marine Public Welfare Research Project of China (grant 201305017), and National Natural Science Foundation of China (40931160435 and 40976090) for financial support.
摘要: Eighteen polyketides (1-18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000319440300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11027
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Nong, Xu-Hua; Zhang, Xiao-Yong; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; [Nong, Xu-Hua] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Zheng, Zhi-Hui; Lu, Xin-Hua] North China Pharmaceutical Grp Corp, New Drug Res & Dev Ctr, Shijiazhuang 052260, Hebei, Peoples R China.Polyketides from a Marine-Derived Fungus Xylariaceae sp.,MARINE DRUGS,2013,11(5):1718-1727
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