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Antiaging activity of low molecular weight peptide from Paphia undulate
[Chen Xin] Foshan Univ, Sch Sci, Foshan 528000, Peoples R China; [Chen Xin; Cai Bingna; Chen Hua; Pan Jianyu; Chen Deke; Sun Huili] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Cai Bingna; Sun Huili] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; shl@scsio.ac.cn
2013
Source PublicationCHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
ISSN0254-4059
Volume31Issue:3Pages:570-580
AbstractLow molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats, aged Kunming mice, ultraviolet-exposed rats, and thermally injured rats was investigated. P. undulate flesh was homogenized and digested using papain under optimal conditions, then subjected to Sephadex G-25 chromatography to isolate the LMWP. Administration of LMWP significantly reversed D-galactose-induced oxidative stress by increasing the activities of glutathione peroxidase (GPx) and catalase (CAT), and by decreasing the level of malondialdehyde (MDA). This process was accompanied by increased collagen synthesis. The LMWP prevented photoaging and promoted dermis recovery and remission of elastic fiber hyperplasia. Furthermore, treatment with the LMWP helped to regenerate elastic fibers and the collagen network, increased superoxide dismutase (SOD) in the serum and significantly decreased MDA. Thermal scald-induced inflammation and edema were also relieved by the LWMP, while wound healing in skin was promoted. These results suggest that the LMWP from P. undulate could serve as a new antiaging substance in cosmetics.
DepartmentLMB
KeywordPaphia Undulate Low Molecular Weight Peptide Antiaging Antiultraviolet Radiation SkIn Wound HealIng In Scald Rats
Subject AreaLimnology ; Oceanography
Funding OrganizationSupported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a)) ; Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a)) ; Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a)) ; Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a))
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Language英语
Funding OrganizationSupported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a)) ; Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a)) ; Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a)) ; Supported by the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-EW-Q214), the Comprehensive Strategic Cooperation Programs between Guangdong Province and Chinese Academy of Sciences (Nos. 2011A090100008, 2009B091300018, 2010B090300027), and the Marine Fisheries Technology Promotion Special Program of Guangdong Province, China (No. A2009009-035(a))
WOS IDWOS:000318719700011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11028
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshl@scsio.ac.cn
Recommended Citation
GB/T 7714
[Chen Xin] Foshan Univ, Sch Sci, Foshan 528000, Peoples R China,[Chen Xin,Cai Bingna,et al. Antiaging activity of low molecular weight peptide from Paphia undulate[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2013,31(3):570-580.
APA [Chen Xin] Foshan Univ, Sch Sci, Foshan 528000, Peoples R China.,[Chen Xin.,Cai Bingna.,Chen Hua.,Pan Jianyu.,...&shl@scsio.ac.cn.(2013).Antiaging activity of low molecular weight peptide from Paphia undulate.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,31(3),570-580.
MLA [Chen Xin] Foshan Univ, Sch Sci, Foshan 528000, Peoples R China,et al."Antiaging activity of low molecular weight peptide from Paphia undulate".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 31.3(2013):570-580.
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