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学科主题: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
题名: Interleukin-17 in pearl oyster (Pinctada fucata): Molecular cloning and functional characterization
作者: [Wu, Shan-Zeng ; Huang, Xian-De ; Li, Qin ; He, Mao-Xian] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: hmx@scsio.ac.cn
关键词: Pearl oyster ; PfIL-17 ; Gene cloning ; Immune response
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2013
卷: 34, 期:5, 页:1050-1056
部门归属: LMB
资助者: The pearl oysters used in the study were reared at Marine Biology Research Station at Daya Bay, Chinese Academy of Sciences, Shenzhen, China. This study was supported by the National Science and technology program of China (2012AA10A410), the Funds of Knowledge Innovation program of Chinese Academy of Sciences (ZCX2-EW-Q21), and the National Natural Science Foundation of China (41176145).
摘要: IL-17 from pearl oyster Pinctada fucata, one of mollusk, was identified and characterized, and its genomic structure and promoter were analyzed. The full-length cDNA of P. fucata IL-17 (PfIL-17) is 907 bp with an open reading frame of 585 bp encoding a putative protein of 194 amino acids. The deduced PfIL-17 contains a 19 amino acid signal peptide and a conserved IL-17 domain. Multiple sequence alignments and phylogenetic analysis revealed that PfIL-17 has lower similarity with other invertebrate IL-17 and was clustered with CgIL-17, but not clustered with other invertebrate IL-17. Gene expression analysis indicated that PfIL-17 took part in the immune response to LPS and poly(I:C) stimulation, and dual-luciferase reporter assays showed that PfIL-17 could active vertebrate target genes containing the NF-kappa B binding site and involve NF-kappa B signal pathway in HEK293 cells. Combined with the results mentioned above, it is suggested that PfIL-17 might involve and activate NF-kappa B signal pathway against extracellular pathogens. (C) 2013 Elsevier Ltd. All rights reserved.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000317870600004
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11037
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Wu, Shan-Zeng; Huang, Xian-De; Li, Qin; He, Mao-Xian] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.Interleukin-17 in pearl oyster (Pinctada fucata): Molecular cloning and functional characterization,FISH & SHELLFISH IMMUNOLOGY,2013,34(5):1050-1056
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