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学科主题: Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
题名: Allograft inflammatory factor-1 stimulates hemocyte immune activation by enhancing phagocytosis and expression of inflammatory cytokines in Crassostrea gigas
作者: [Zhang, Yang ; Li, Jun ; Yu, Feng ; He, Xiaocui ; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: carlzyu@scsio.ac.cn
关键词: Crassostrea gigas ; AIF-1 ; Hemocyte activation ; Phagocytosis ; Inflammatory cytokine
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2013
卷: 34, 期:5, 页:1071-1077
部门归属: LMB
资助者: This work was supported by the National Science Foundation of China (No. 31001130 and 41176150), the National Basic Research Program of China (No. 2010CB126404) and the Joint Funds of NSFC-Guangdong of China (U1201215). We also thank Prof. Elizabeth De Stasio for critical reading and editing of the manuscript.
摘要: Allograft inflammatory factor-1 (AIF-1) is a calcium-binding cytokine associated with immune cell activation and inflammatory response. Presently, we have identified and characterized an AIF-1 in a marine bivalve mollusk, Crassostrea gigas, and designated it as CgAIF-1. The full-length CgAIF-1 cDNA is 794 bp, encoding a protein of 149 amino acids with two conserved EF hand Ca2+-binding motifs. CgAIF-1 is constitutively expressed in various tissues with enriched expression in hemocytes. Moreover, CgAIF-1 transcription is induced by multiple Pathogen-Associated Molecular Patterns (PAMPs), including poly (I: C), LPS, PGN, HKLM and HKVA, but is limited by 1,3-beta-glucan. Furthermore, recombinant CgAIF-1 can specifically stimulate phagocytic ability of granulocytes, but not of intermediate cells and hyalinocytes. CgAIF-1 also enhances mRNA levels of MIF, TNF and IL-17. These results provide the first functional evidence that CgAIF-1 is involved in hemocyte activation in C gigas, revealing conserved functions of AIF-1 in host defense from mollusks to mammals. (C) 2013 Elsevier Ltd. All rights reserved.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000317870600007
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11038
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[Zhang, Yang; Li, Jun; Yu, Feng; He, Xiaocui; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China.Allograft inflammatory factor-1 stimulates hemocyte immune activation by enhancing phagocytosis and expression of inflammatory cytokines in Crassostrea gigas,FISH & SHELLFISH IMMUNOLOGY,2013,34(5):1071-1077
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