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The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas
[Zhang, Yang; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; carlzyu@scsio.ac.cn
2013
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume34Issue:5Pages:1352-1355
AbstractThe oyster Crassostrea gigas is thought to have developed effective immunity to potentially harmful pathogens while under continuous exposure to marine microorganisms; however, the evolutionary mechanisms by which such immunity developed has not been understood. To understand the evolution of immunity, we characterized the family of peptidoglycan recognition proteins in the oyster (CgPGRPs). These proteins are crucial pattern recognition receptors for peptidoglycans (PGNs) and thereby, for activating the innate immune response of host. Herein, we identify seven new CgPGRP genes. Phylogenetic analysis of the seven new and five previously reported CgPRGP genes reveals that the CgPRGP gene family can be clustered into two groups, CgPRGPS and CgPRGPL. Moreover, the CgPRGPS group can be further divided into five subgroups. A codon-substitution model and three likelihood ratio tests (LRTs) suggest that seven sites in the CgPGRP family of genes have been subjected to strong positive selection (omega = 3.035-4.143), Three dimensional modeling revealed that these sites are found primarily at the periphery of coils and alpha-helices rather than in beta-strands, perhaps allowing PGRP to adapt to, and recognize, variability of PGN structure. In conclusion, our studies provide the first evidence of positive Darwinian selection in the CgPGRP family, contributing to a better understanding of the adaptive mechanism of host-pathogens interaction in marine mollusks. (C) 2013 Elsevier Ltd. All rights reserved.
DepartmentLMB
KeywordPositive Selection Peptidoglycan Recognition Protein Crassostrea Gigas
Subject AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
Funding OrganizationThis work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript.
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Language英语
Funding OrganizationThis work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript.
WOS IDWOS:000317870600041
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11041
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorcarlzyu@scsio.ac.cn
Recommended Citation
GB/T 7714
[Zhang, Yang,Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China,carlzyu@scsio.ac.cn. The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2013,34(5):1352-1355.
APA [Zhang, Yang,Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China,&carlzyu@scsio.ac.cn.(2013).The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,34(5),1352-1355.
MLA [Zhang, Yang,et al."The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 34.5(2013):1352-1355.
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