The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas
[Zhang, Yang; Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; carlzyu@scsio.ac.cn
2013
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
卷号34期号:5页码:1352-1355
摘要The oyster Crassostrea gigas is thought to have developed effective immunity to potentially harmful pathogens while under continuous exposure to marine microorganisms; however, the evolutionary mechanisms by which such immunity developed has not been understood. To understand the evolution of immunity, we characterized the family of peptidoglycan recognition proteins in the oyster (CgPGRPs). These proteins are crucial pattern recognition receptors for peptidoglycans (PGNs) and thereby, for activating the innate immune response of host. Herein, we identify seven new CgPGRP genes. Phylogenetic analysis of the seven new and five previously reported CgPRGP genes reveals that the CgPRGP gene family can be clustered into two groups, CgPRGPS and CgPRGPL. Moreover, the CgPRGPS group can be further divided into five subgroups. A codon-substitution model and three likelihood ratio tests (LRTs) suggest that seven sites in the CgPGRP family of genes have been subjected to strong positive selection (omega = 3.035-4.143), Three dimensional modeling revealed that these sites are found primarily at the periphery of coils and alpha-helices rather than in beta-strands, perhaps allowing PGRP to adapt to, and recognize, variability of PGN structure. In conclusion, our studies provide the first evidence of positive Darwinian selection in the CgPGRP family, contributing to a better understanding of the adaptive mechanism of host-pathogens interaction in marine mollusks. (C) 2013 Elsevier Ltd. All rights reserved.
部门归属LMB
关键词Positive Selection Peptidoglycan Recognition Protein Crassostrea Gigas
学科领域Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
资助者This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript.
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资助者This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript. ; This work was supported by a National Science Foundation of China (No.41176150), a National Basic Research Program of China (No. 2010CB126404) and a Joint Funds of NSFC-Guangdong of China (U1201215). We thank Prof. Elizabeth De Stasio for her editing of the manuscript.
WOS记录号WOS:000317870600041
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11041
专题中科院海洋生物资源可持续利用重点实验室
通讯作者carlzyu@scsio.ac.cn
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[Zhang, Yang,Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China,carlzyu@scsio.ac.cn. The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2013,34(5):1352-1355.
APA [Zhang, Yang,Yu, Ziniu] Chinese Acad Sci, South China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China,&carlzyu@scsio.ac.cn.(2013).The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,34(5),1352-1355.
MLA [Zhang, Yang,et al."The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 34.5(2013):1352-1355.
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