Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037
[Wu, Zheng-Chao; Li, Sumei; Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China; [Wu, Zheng-Chao] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA; [Wu, Zheng-Chao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea; [Liu, Zhong] Jinan Univ, Guangdong Key Lab Bioengn Med, Guangzhoujinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China; czhang2006@gmail.com
2013
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:4页码:694-701
摘要Two new cyclic hexapeptides, nocardiamides A (1) and B (2), were isolated from the culture broth of marine-derived actinomycete CNX037 strain that was identified as a Nocardiopsis species. The planar structures of nocardiamides A (1) and B (2) were assigned on the basis of ID and 2D NMR and HRESIMS spectroscopic analyses. Their absolute configurations were deduced by the advanced Marfey's method and chiral-phase HPLC analysis. The challenge of locating two D- and one L-valine residue in 1 and 2 was accomplished by total synthesis using solid-phase peptide synthetic methods. Both 1 and 2 showed negligible antimicrobial activities against seven indicator strains and exhibited no cytotoxicity against HCT-116.
部门归属LMB
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002). ; We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002). ; We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002). ; We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002).
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资助者We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002). ; We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002). ; We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002). ; We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002).
WOS记录号WOS:000318264700029
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11042
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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[Wu, Zheng-Chao,Li, Sumei,Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China,et al. Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(4):694-701.
APA [Wu, Zheng-Chao.,Li, Sumei.,Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China.,[Wu, Zheng-Chao] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA.,[Wu, Zheng-Chao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.,...&czhang2006@gmail.com.(2013).Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037.JOURNAL OF NATURAL PRODUCTS,76(4),694-701.
MLA [Wu, Zheng-Chao,et al."Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037".JOURNAL OF NATURAL PRODUCTS 76.4(2013):694-701.
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