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学科主题: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
题名: Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037
作者: [Wu, Zheng-Chao ; Li, Sumei ; Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China ; [Wu, Zheng-Chao] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA ; [Wu, Zheng-Chao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea ; [Liu, Zhong] Jinan Univ, Guangdong Key Lab Bioengn Med, Guangzhoujinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China
通讯作者: czhang2006@gmail.com
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2013
卷: 76, 期:4, 页:694-701
部门归属: LMB
资助者: We sincerely appreciate Prof. W. Fenical (Scripps Institution of Oceanography, UCSD) for providing laboratory facilities to initiate this work, his insightful advice to support this work, and his critical reading of the manuscript. We thank Dr. P. Jensen's group (SIO) for the generous gift of the strain CNX037. We also thank C. Kauffman (SIO) for fermentation assistance and L. Paul (SIO) for performing the HCT-116 cytotoxicity bioassay. This study was supported in part by the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-JC202, KSCX2-EW-G-12), the Ministry of Science and Technology of China (2012AA091606, 2010CB833805), and National Science Foundation of China (41006089, 31125001). Z.W. was supported by a scholarship under the State Scholarship Fund (2010491110) from the China Scholarship Council. C.Z. is a scholar of the "100 Talents Project" of the Chinese Academy of Sciences (08SL111002).
摘要: Two new cyclic hexapeptides, nocardiamides A (1) and B (2), were isolated from the culture broth of marine-derived actinomycete CNX037 strain that was identified as a Nocardiopsis species. The planar structures of nocardiamides A (1) and B (2) were assigned on the basis of ID and 2D NMR and HRESIMS spectroscopic analyses. Their absolute configurations were deduced by the advanced Marfey's method and chiral-phase HPLC analysis. The challenge of locating two D- and one L-valine residue in 1 and 2 was accomplished by total synthesis using solid-phase peptide synthetic methods. Both 1 and 2 showed negligible antimicrobial activities against seven indicator strains and exhibited no cytotoxicity against HCT-116.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000318264700029
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11042
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
[Wu, Zheng-Chao; Li, Sumei; Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China; [Wu, Zheng-Chao] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA; [Wu, Zheng-Chao] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea; [Liu, Zhong] Jinan Univ, Guangdong Key Lab Bioengn Med, Guangzhoujinan Biomed Res & Dev Ctr, Guangzhou 510632, Guangdong, Peoples R China.Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp CNX037,JOURNAL OF NATURAL PRODUCTS,2013,76(4):694-701
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