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学科主题: Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
题名: Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023
作者: [Bao, Jie ; Sun, Yu-Lin ; Zhang, Xiao-Yong ; Han, Zhuang ; He, Fei ; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China ; [Bao, Jie ; Sun, Yu-Lin ; Han, Zhuang] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China ; [Gao, Hai-Chun] Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China ; [Qian, Pei-Yuan] Hong Kong Univ Sci & Technol, Dept Biol, Kln, Hong Kong, Peoples R China
通讯作者: shuhuaqi@scsio.ac.cn
关键词: antifouling ; antibacterial ; gorgonian coral-associated fungus ; Penicillium sp. ; polyketide
刊名: JOURNAL OF ANTIBIOTICS
发表日期: 2013
卷: 66, 期:4, 页:219-223
部门归属: LMB
资助者: We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support.
摘要: Two new polyketides, 6,8,5'6'-tetrahydroxy-3'-methylflavone (1) and paecilin C (2), together with six known analogs secalonic acid D (3), secalonic acid B (4) penicillixanthone A (5), emodin (6), citreorosein (7) and isorhodoptilometrin (8) were obtained from a broth of gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023. Compounds 1 and 6-8 had significant antifouling activity against Balanus amphitrite larvae settlement with EC50 values of 6.7, 6.1, 17.9 and 13.7 mu gml(-1), respectively, and 3-5 showed medium antibacterial activity against four tested bacterial strains. This was the first report of antibacterial activity of 3-5 against marine bacteria and antifouling activity of 6-8 against marine biofouling organism's larvae. The results indicated that gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023 strain could produce antifouling and antibacterial compounds that might aid the host gorgonian coral in protection against marine pathogen bacteria, biofouling organisms and other intruders.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000318348100004
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11043
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Bao, Jie; Sun, Yu-Lin; Zhang, Xiao-Yong; Han, Zhuang; He, Fei; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China; [Bao, Jie; Sun, Yu-Lin; Han, Zhuang] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Gao, Hai-Chun] Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China; [Qian, Pei-Yuan] Hong Kong Univ Sci & Technol, Dept Biol, Kln, Hong Kong, Peoples R China.Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023,JOURNAL OF ANTIBIOTICS,2013,66(4):219-223
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