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Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023
[Bao, Jie; Sun, Yu-Lin; Zhang, Xiao-Yong; Han, Zhuang; He, Fei; Qi, Shu-Hua] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China; Han, Zhuang] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Gao, Hai-Chun] Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China; [Qian, Pei-Yuan] Hong Kong Univ Sci & Technol, Dept Biol, Kln, Hong Kong, Peoples R China; shuhuaqi@scsio.ac.cn
2013
Source PublicationJOURNAL OF ANTIBIOTICS
ISSN0021-8820
Volume66Issue:4Pages:219-223
AbstractTwo new polyketides, 6,8,5'6'-tetrahydroxy-3'-methylflavone (1) and paecilin C (2), together with six known analogs secalonic acid D (3), secalonic acid B (4) penicillixanthone A (5), emodin (6), citreorosein (7) and isorhodoptilometrin (8) were obtained from a broth of gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023. Compounds 1 and 6-8 had significant antifouling activity against Balanus amphitrite larvae settlement with EC50 values of 6.7, 6.1, 17.9 and 13.7 mu gml(-1), respectively, and 3-5 showed medium antibacterial activity against four tested bacterial strains. This was the first report of antibacterial activity of 3-5 against marine bacteria and antifouling activity of 6-8 against marine biofouling organism's larvae. The results indicated that gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023 strain could produce antifouling and antibacterial compounds that might aid the host gorgonian coral in protection against marine pathogen bacteria, biofouling organisms and other intruders.
DepartmentLMB
KeywordAntifouling Antibacterial Gorgonian Coral-associated Fungus Penicillium Sp. Polyketide
Subject AreaBiotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
Funding OrganizationWe are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support. ; We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support. ; We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support. ; We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support.
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Language英语
Funding OrganizationWe are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support. ; We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support. ; We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support. ; We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2 YW T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support.
WOS IDWOS:000318348100004
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11043
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorshuhuaqi@scsio.ac.cn
Recommended Citation
GB/T 7714
[Bao, Jie,Sun, Yu-Lin,Zhang, Xiao-Yong,et al. Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023[J]. JOURNAL OF ANTIBIOTICS,2013,66(4):219-223.
APA [Bao, Jie.,Sun, Yu-Lin.,Zhang, Xiao-Yong.,Han, Zhuang.,He, Fei.,...&shuhuaqi@scsio.ac.cn.(2013).Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023.JOURNAL OF ANTIBIOTICS,66(4),219-223.
MLA [Bao, Jie,et al."Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023".JOURNAL OF ANTIBIOTICS 66.4(2013):219-223.
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