Knowledge Management System Of South China Sea Institute of Oceanology,CAS
| Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation | |
| [Wang, Bo; Song, Yongxiang; Luo, Minghe; Chen, Qi; Ma, Junying; Huang, Hongbo; Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; jju@scsio.ac.cn | |
| 2013 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 15Issue:6Pages:1278-1281 |
| Abstract | 9-Methylstreptimidone is a glutarimide antibiotic showing antiviral, antifungal, and antitumor activities. Genome scanning, bioinformatics analysis, and gene inactivation experiments reveal a gene cluster responsible for the biosynthesis of 9-methylstreptimidone in Streptomyces himastatinicus. The unveiled machinery features both acyltransferase- and thioesterase-less iterative use of module 5 as well as a branching module for glutarimide generation. Impressively, inactivation of smdK leads to a new carboxylate analogue unveiling a new mechanism for polyketide terminal diene formation. |
| Department | LMB |
| Subject Area | Chemistry, Organic |
| Funding Organization | This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). |
| URL | 查看原文 |
| Language | 英语 |
| Funding Organization | This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). |
| WOS ID | WOS:000316520300032 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.scsio.ac.cn/handle/344004/11051 |
| Collection | 中科院海洋生物资源可持续利用重点实验室 |
| Corresponding Author | jju@scsio.ac.cn |
| Recommended Citation GB/T 7714 | [Wang, Bo,Song, Yongxiang,Luo, Minghe,et al. Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation[J]. ORGANIC LETTERS,2013,15(6):1278-1281. |
| APA | [Wang, Bo.,Song, Yongxiang.,Luo, Minghe.,Chen, Qi.,Ma, Junying.,...&jju@scsio.ac.cn.(2013).Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation.ORGANIC LETTERS,15(6),1278-1281. |
| MLA | [Wang, Bo,et al."Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation".ORGANIC LETTERS 15.6(2013):1278-1281. |
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| Biosynthesis of 9-Me（493KB） | 开放获取 | CC BY-NC-SA | Application Full Text | |||
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