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学科主题: Chemistry, Organic
题名: Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation
作者: [Wang, Bo ; Song, Yongxiang ; Luo, Minghe ; Chen, Qi ; Ma, Junying ; Huang, Hongbo ; Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: jju@scsio.ac.cn
刊名: ORGANIC LETTERS
发表日期: 2013
卷: 15, 期:6, 页:1278-1281
部门归属: LMB
资助者: This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001).
摘要: 9-Methylstreptimidone is a glutarimide antibiotic showing antiviral, antifungal, and antitumor activities. Genome scanning, bioinformatics analysis, and gene inactivation experiments reveal a gene cluster responsible for the biosynthesis of 9-methylstreptimidone in Streptomyces himastatinicus. The unveiled machinery features both acyltransferase- and thioesterase-less iterative use of module 5 as well as a branching module for glutarimide generation. Impressively, inactivation of smdK leads to a new carboxylate analogue unveiling a new mechanism for polyketide terminal diene formation.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000316520300032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11051
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Wang, Bo; Song, Yongxiang; Luo, Minghe; Chen, Qi; Ma, Junying; Huang, Hongbo; Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China.Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation,ORGANIC LETTERS,2013,15(6):1278-1281
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文件名: Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation.pdf
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