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Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation
[Wang, Bo; Song, Yongxiang; Luo, Minghe; Chen, Qi; Ma, Junying; Huang, Hongbo; Ju, Jianhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; jju@scsio.ac.cn
2013
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume15Issue:6Pages:1278-1281
Abstract9-Methylstreptimidone is a glutarimide antibiotic showing antiviral, antifungal, and antitumor activities. Genome scanning, bioinformatics analysis, and gene inactivation experiments reveal a gene cluster responsible for the biosynthesis of 9-methylstreptimidone in Streptomyces himastatinicus. The unveiled machinery features both acyltransferase- and thioesterase-less iterative use of module 5 as well as a branching module for glutarimide generation. Impressively, inactivation of smdK leads to a new carboxylate analogue unveiling a new mechanism for polyketide terminal diene formation.
DepartmentLMB
Subject AreaChemistry, Organic
Funding OrganizationThis work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001).
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Language英语
Funding OrganizationThis work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001). ; This work was supported by MOST (2010CB833805, 2012AA092104) and the Knowledge Innovation Programs of CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, and 08SL111001).
WOS IDWOS:000316520300032
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11051
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorjju@scsio.ac.cn
Recommended Citation
GB/T 7714
[Wang, Bo,Song, Yongxiang,Luo, Minghe,et al. Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation[J]. ORGANIC LETTERS,2013,15(6):1278-1281.
APA [Wang, Bo.,Song, Yongxiang.,Luo, Minghe.,Chen, Qi.,Ma, Junying.,...&jju@scsio.ac.cn.(2013).Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation.ORGANIC LETTERS,15(6),1278-1281.
MLA [Wang, Bo,et al."Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation".ORGANIC LETTERS 15.6(2013):1278-1281.
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