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学科主题: Chemistry, Organic
题名: Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase
作者: [Li, Sumei ; Xiao, Ji ; Zhu, Yiguang ; Zhang, Guangtao ; Yang, Chunfang ; Zhang, Haibo ; Ma, Liang ; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China ; [Xiao, Ji] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者: czhang2006@gmail.com
刊名: ORGANIC LETTERS
发表日期: 2013
卷: 15, 期:6, 页:1374-1377
部门归属: LMB
资助者: This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data.
摘要: The Identification of a lobophorin biosynthetic gene cluster from the deep-sea derived Streptomyces sp. SCSIO 01127 reveals a paradigm of three glycosyltransferases (GTs) LobG1-LobG3 being responsible for appending four sugars. Characterization of five differentially glycosylated metabolites from three GT gene-inactivation mutants allowed the assignment of GT functions and the implication of LobG3 as an iterative GT to attach two digitoxoses.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000316520300056
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11052
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Li, Sumei; Xiao, Ji; Zhu, Yiguang; Zhang, Guangtao; Yang, Chunfang; Zhang, Haibo; Ma, Liang; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; [Xiao, Ji] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China.Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase,ORGANIC LETTERS,2013,15(6):1374-1377
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文件名: Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase.pdf
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