Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase
[Li, Sumei; Xiao, Ji; Zhu, Yiguang; Zhang, Guangtao; Yang, Chunfang; Zhang, Haibo; Ma, Liang; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China; [Xiao, Ji] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; czhang2006@gmail.com
2013
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号15期号:6页码:1374-1377
摘要The Identification of a lobophorin biosynthetic gene cluster from the deep-sea derived Streptomyces sp. SCSIO 01127 reveals a paradigm of three glycosyltransferases (GTs) LobG1-LobG3 being responsible for appending four sugars. Characterization of five differentially glycosylated metabolites from three GT gene-inactivation mutants allowed the assignment of GT functions and the implication of LobG3 as an iterative GT to attach two digitoxoses.
部门归属LMB
学科领域Chemistry, Organic
资助者This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data. ; This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data. ; This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data. ; This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data.
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语种英语
资助者This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data. ; This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data. ; This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data. ; This work is supported in part by NSFC (31125001), CAS (KZCX2-YW-JC202, KSCX2-EW-G-12, 08SL111002), and MOST (2010CB833805 and 2012AA092104). We are grateful to the analytical facility at SCSIO for recording NMR data.
WOS记录号WOS:000316520300056
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/11052
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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[Li, Sumei,Xiao, Ji,Zhu, Yiguang,et al. Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase[J]. ORGANIC LETTERS,2013,15(6):1374-1377.
APA [Li, Sumei.,Xiao, Ji.,Zhu, Yiguang.,Zhang, Guangtao.,Yang, Chunfang.,...&czhang2006@gmail.com.(2013).Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase.ORGANIC LETTERS,15(6),1374-1377.
MLA [Li, Sumei,et al."Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase".ORGANIC LETTERS 15.6(2013):1374-1377.
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