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学科主题: Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
题名: Marine Natural Products with Anti-HIV Activities in the Last Decade
作者: [Zhou, Xuefeng ; Liu, Juan ; Yang, Bin ; Lin, Xiuping ; Yang, Xian-Wen ; Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China
通讯作者: yonghongliu@scsio.ac.cn
关键词: Anti-HIV ; HIV entry inhibitors ; last decade ; marine organisms ; natural products ; sponges
刊名: CURRENT MEDICINAL CHEMISTRY
发表日期: 2013
卷: 20, 期:7, 页:953-973
部门归属: LMB
资助者: This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019).
摘要: Marine organisms have been proven to be excellent sources of biologically active compounds against HIV. This review gives an overview of 132 natural products from marine sources obtained during the last decade (2002-2011), which exhibit anti-HIV activity toward different biological targets. Sponges contribute more than half of all anti-HIV natural products from marine organisms, mainly as alkaloids and cyclic depsipeptides. In addition, some macromolecules are considered as potential anti-HIV agents, including lectins from algae and marine invertebrates, as well as sulfated polysaccharides from algae. In the reviewed marine natural products, many active ingredients act as HIV entry inhibitors, one class of new anti-HIV agents, and may be regarded as potential candidates for the development of novel anti-HIV agents. The other features of development in the marine original anti-HIV natural products in this ten years are also discussed.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000316610600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11063
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[Zhou, Xuefeng; Liu, Juan; Yang, Bin; Lin, Xiuping; Yang, Xian-Wen; Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China.Marine Natural Products with Anti-HIV Activities in the Last Decade,CURRENT MEDICINAL CHEMISTRY,2013,20(7):953-973
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