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Marine Natural Products with Anti-HIV Activities in the Last Decade
[Zhou, Xuefeng; Liu, Juan; Yang, Bin; Lin, Xiuping; Yang, Xian-Wen; Liu, Yonghong] Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China; yonghongliu@scsio.ac.cn
2013
Source PublicationCURRENT MEDICINAL CHEMISTRY
ISSN0929-8673
Volume20Issue:7Pages:953-973
AbstractMarine organisms have been proven to be excellent sources of biologically active compounds against HIV. This review gives an overview of 132 natural products from marine sources obtained during the last decade (2002-2011), which exhibit anti-HIV activity toward different biological targets. Sponges contribute more than half of all anti-HIV natural products from marine organisms, mainly as alkaloids and cyclic depsipeptides. In addition, some macromolecules are considered as potential anti-HIV agents, including lectins from algae and marine invertebrates, as well as sulfated polysaccharides from algae. In the reviewed marine natural products, many active ingredients act as HIV entry inhibitors, one class of new anti-HIV agents, and may be regarded as potential candidates for the development of novel anti-HIV agents. The other features of development in the marine original anti-HIV natural products in this ten years are also discussed.
DepartmentLMB
KeywordAnti-hiv Hiv Entry Inhibitors Last Decade Marine Organisms Natural Products Sponges
Subject AreaBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
Funding OrganizationThis work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). ; This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). ; This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). ; This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019).
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Language英语
Funding OrganizationThis work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). ; This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). ; This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019). ; This work was supported by grants from the National Natural Science Foundation of China (20902094 and 30973679, 21172230), National High Technology Research and Development Program of China (863 Program, 2012AA092104), National Key Basic Research Program of China (973)'s Project (2010CB833800 and 2011CB915503), and Knowledge Innovation Program of Chinese Academy of Sciences (SQ201019).
WOS IDWOS:000316610600009
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11063
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoryonghongliu@scsio.ac.cn
Recommended Citation
GB/T 7714
[Zhou, Xuefeng,Liu, Juan,Yang, Bin,et al. Marine Natural Products with Anti-HIV Activities in the Last Decade[J]. CURRENT MEDICINAL CHEMISTRY,2013,20(7):953-973.
APA [Zhou, Xuefeng.,Liu, Juan.,Yang, Bin.,Lin, Xiuping.,Yang, Xian-Wen.,...&yonghongliu@scsio.ac.cn.(2013).Marine Natural Products with Anti-HIV Activities in the Last Decade.CURRENT MEDICINAL CHEMISTRY,20(7),953-973.
MLA [Zhou, Xuefeng,et al."Marine Natural Products with Anti-HIV Activities in the Last Decade".CURRENT MEDICINAL CHEMISTRY 20.7(2013):953-973.
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