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学科主题: Biotechnology & Applied Microbiology ; Genetics & Heredity
题名: Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome
作者: [Shi, Wei ; Kong, Xiao-Yu ; Wang, Zhong-Ming ; Yu, Shan-Shan] Chinese Acad Sci, Key Lab Marine Bioresource Sustainable Utilizat L, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China ; [Chen, Hai-Xia] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden ; [De Stasio, Elizabeth A.] Lawrence Univ, Dept Biol, Appleton, WI 54911 USA
通讯作者: xykong@scsio.ac.cn
刊名: BMC GENOMICS
发表日期: 2013
卷: 14, 页:-103
部门归属: LMB
资助者: This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice.
摘要: Background: Tandem repeats (TRs) in the mitochondrial (mt) genome control region have been documented in a wide variety of vertebrate species. The mechanism by which repeated tracts originate and undergo duplication and deletion, however, remains unclear. Results: We analyzed DNA sequences of mt genome TRs (mtTRs) in the ridged-eye flounder (Pleuronichthys cornutus), and characterized DNA sequences of mtTRs from other vertebrates using the data available in GenBank. Tandem repeats are concentrated in the control regions; however, we found approximately 16.6% of the TRs elsewhere in the mt genome. The flounder mtTRs possess three motif types with hypervariable characteristics at the 30 end of the control region (CR). Conclusion: Based on our analysis of this larger dataset of mtTR sequences, we propose a novel model of Pause Melting Misalignment (PMM) to describe the birth and motif indel of tandem repeats. PMM is activated during a pause event in mitochondrial replication in which a dynamic competition between the nascent (N) heavy strand and the displaced (D) heavy strand may lead to the melting of the N-strand from the template (T) light strand. When mispairing occurs during rebinding of the N-strand, one or several motifs can be inserted or deleted in both strands during the next round of mt-replication or repair. This model can explain the characteristics of TRs in available vertebrate mt genomes.
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000316007600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/11069
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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[Shi, Wei; Kong, Xiao-Yu; Wang, Zhong-Ming; Yu, Shan-Shan] Chinese Acad Sci, Key Lab Marine Bioresource Sustainable Utilizat L, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Hai-Xia] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden; [De Stasio, Elizabeth A.] Lawrence Univ, Dept Biol, Appleton, WI 54911 USA.Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome,BMC GENOMICS,2013,14():-103
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