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Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome
[Shi, Wei; Kong, Xiao-Yu; Wang, Zhong-Ming; Yu, Shan-Shan] Chinese Acad Sci, Key Lab Marine Bioresource Sustainable Utilizat L, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Hai-Xia] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden; [De Stasio, Elizabeth A.] Lawrence Univ, Dept Biol, Appleton, WI 54911 USA; xykong@scsio.ac.cn
2013
Source PublicationBMC GENOMICS
ISSN1471-2164
Volume14Pages:-103
AbstractBackground: Tandem repeats (TRs) in the mitochondrial (mt) genome control region have been documented in a wide variety of vertebrate species. The mechanism by which repeated tracts originate and undergo duplication and deletion, however, remains unclear. Results: We analyzed DNA sequences of mt genome TRs (mtTRs) in the ridged-eye flounder (Pleuronichthys cornutus), and characterized DNA sequences of mtTRs from other vertebrates using the data available in GenBank. Tandem repeats are concentrated in the control regions; however, we found approximately 16.6% of the TRs elsewhere in the mt genome. The flounder mtTRs possess three motif types with hypervariable characteristics at the 30 end of the control region (CR). Conclusion: Based on our analysis of this larger dataset of mtTR sequences, we propose a novel model of Pause Melting Misalignment (PMM) to describe the birth and motif indel of tandem repeats. PMM is activated during a pause event in mitochondrial replication in which a dynamic competition between the nascent (N) heavy strand and the displaced (D) heavy strand may lead to the melting of the N-strand from the template (T) light strand. When mispairing occurs during rebinding of the N-strand, one or several motifs can be inserted or deleted in both strands during the next round of mt-replication or repair. This model can explain the characteristics of TRs in available vertebrate mt genomes.
DepartmentLMB
Subject AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
Funding OrganizationThis work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. ; This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. ; This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. ; This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice.
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Language英语
Funding OrganizationThis work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. ; This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. ; This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice. ; This work was supported by the Natural Science Foundation of China (30870283, 31071890). We thank Prof. Ziniu Yu and Dr. Xiangyun Wu for critical review and advice.
WOS IDWOS:000316007600001
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Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/11069
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorxykong@scsio.ac.cn
Recommended Citation
GB/T 7714
[Shi, Wei,Kong, Xiao-Yu,Wang, Zhong-Ming,et al. Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome[J]. BMC GENOMICS,2013,14:-103.
APA [Shi, Wei.,Kong, Xiao-Yu.,Wang, Zhong-Ming.,Yu, Shan-Shan] Chinese Acad Sci, Key Lab Marine Bioresource Sustainable Utilizat L, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China.,[Chen, Hai-Xia] Univ Gothenburg, Dept Biol & Environm Sci, SE-40530 Gothenburg, Sweden.,...&xykong@scsio.ac.cn.(2013).Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome.BMC GENOMICS,14,-103.
MLA [Shi, Wei,et al."Pause-melting misalignment: a novel model for the birth and motif indel of tandem repeats in the mitochondrial genome".BMC GENOMICS 14(2013):-103.
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