Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis
[Fu, Ka-Li; Shen, Yun-Heng; Lu, Lu; Li, Bo; Yang, Xian-Wen; Su, Juan; Liu, Run-Hui; Zhang, Wei-Dong] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China; [Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China; [Li, Bo] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; shenyunheng9217018@yahoo.com.cn; wdzhangy@hotmail.com
2013
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号96期号:2页码:338-344
摘要Two unusual rearranged flavan derivatives with a rare bicyclo[3.3.1]non-3-ene-2,9-dione ring, tazettone A (1) and tazettone B (2), together with five known flavans, 3-7, were isolated from the bulbs of Narcissus tazetta var. chinensis Roem. The structures of two new compounds were elucidated by spectroscopic analyses, including 1D- and 2D-NMR spectroscopy. All of the isolated compounds were evaluated for their cytotoxicities against four human tumor cell lines A549, HCT116, SK-BR-3, and HepG2. Compounds 1 and 2 were almost inactive against all tested cell lines, while compounds 3-7 exhibited moderate or weak cytotoxicities against the tested cell lines.
部门归属LMB
学科领域Chemistry, Multidisciplinary
资助者The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06). ; The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06). ; The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06). ; The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06).
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语种英语
资助者The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06). ; The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06). ; The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06). ; The work was supported by program NCET Foundation, NSFC (30725045), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research for Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Scientific Foundation of Shanghai, P. R. China (09DZ1975700, 09DZ1971500,10DZ1971700, 11DZ1970601, 11DZ1970602). The Twelfth Five-Year National Science & Technology Support Program (Number: 2012BAI29B06).
WOS记录号WOS:000316274600019
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条目标识符http://ir.scsio.ac.cn/handle/344004/11070
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shenyunheng9217018@yahoo.com.cn; wdzhangy@hotmail.com
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[Fu, Ka-Li,Shen, Yun-Heng,Lu, Lu,et al. Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis[J]. HELVETICA CHIMICA ACTA,2013,96(2):338-344.
APA [Fu, Ka-Li.,Shen, Yun-Heng.,Lu, Lu.,Li, Bo.,Yang, Xian-Wen.,...&wdzhangy@hotmail.com.(2013).Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis.HELVETICA CHIMICA ACTA,96(2),338-344.
MLA [Fu, Ka-Li,et al."Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis".HELVETICA CHIMICA ACTA 96.2(2013):338-344.
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