Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea
作者:
[Sun, Jian-Fan
; Zhou, Xue-Feng
; Yang, Bin
; Lin, Xiuping
; Liu, Juan
; Peng, Yan
; Yang, Xian-Wen
; Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, Guangzhou 510301, Guangdong, Peoples R China
; [Sun, Jian-Fan] Jiangsu Univ, Sch Environm, Zhenjiang 212013, Peoples R China
; [Han, Zhuang] Hong Kong Univ Sci & Technol, Div Life Sci, Sect Marine Ecol & Biotechnol, KAUST Global Acad Partnership Program, Hong Kong, Hong Kong, Peoples R China
Our continued investigation on the South China Sea gorgonian Dichotella gemmacea led to the isolation of 16 new briarane-type diterpenoids, dichotellides F-U (1-16), along with 18 known analogues (17-34). Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in literature. The absolute configuration of 15 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 3, 4, 6-11, 16, and 23 had potent antifouling activities at nontoxic concentrations with EC50 values of 4.1, 1.82, 6.3, 7.6, 4.6, 1.2, 5.6, 0.79, 2.0, and 0.2 mu g/mL, respectively. (c) 2012 Elsevier Ltd. All rights reserved.
